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Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro
http://hdl.handle.net/10422/00013286
http://hdl.handle.net/10422/000132866dab9ad4-7e7f-4d64-9255-3ab07ac71779
名前 / ファイル | ライセンス | アクション |
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s42003-022-03312-0 (9.2 MB)
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-25 | |||||
タイトル | ||||||
タイトル | Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cellular neuroscience | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neural ageing | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
ASADA-UTSUGI, Megumi
× ASADA-UTSUGI, Megumi× UEMURA, Kengo× Ayaki, Takashi× UEMURA, Maiko T× MINAMIYAMA, Sumio× HIKIAMI, Ryota× MORIMURA, Toshifumi× SHODAI, Akemi× UEKI, Takatoshi× TAKAHASHI, Ryosuke× KINOSHITA, Ayae× URUSHITANI, Makoto |
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著者別名 |
浅田, めぐみ
× 浅田, めぐみ× 南山, 素三雄× 引網, 亮太× 守村, 敏史× 小代, 明美× 漆谷, 真 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells. Since tau is a microtubule-associated protein, we investigate whether DSB is involved in tau pathologies in Alzheimer's disease (AD). First, immunohistochemistry reveals the frequent coexistence of DSB and phosphorylated tau in the cortex of AD patients. In vitro studies using primary mouse cortical neurons show that non-p-tau accumulates perinuclearly together with the tubulin after DSB induction with etoposide, followed by the accumulation of phosphorylated tau. Moreover, the knockdown of endogenous tau exacerbates DSB in neurons, suggesting the protective role of tau on DNA repair. Interestingly, synergistic exposure of neurons to microtubule disassembly and the DSB strikingly augments aberrant p-tau aggregation and apoptosis. These data suggest that DSB plays a pivotal role in AD-tau pathology and that the failure of DSB repair leads to tauopathy. | |||||
書誌情報 |
en : Communications Biology 巻 5, 号 1, 発行日 2022-04-13 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2399-3642 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35418705 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s42003-022-03312-0 | |||||
関連名称 | 10.1038/s42003-022-03312-0 | |||||
権利 | ||||||
権利情報 | © 2022. The Author(s). | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |