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Benefit Profile of Thrombomodulin Alfa Combined with Antithrombin Concentrate in Patients with Sepsis-Induced Disseminated Intravascular Coagulation.
http://hdl.handle.net/10422/00013228
http://hdl.handle.net/10422/00013228f5c86080-7b0e-44db-bb82-73dabc571053
名前 / ファイル | ライセンス | アクション |
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10760296221077096 (1.2 MB)
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This article is distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
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Supplementary material (178.8 kB)
|
This article is distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-03-03 | |||||
タイトル | ||||||
タイトル | Benefit Profile of Thrombomodulin Alfa Combined with Antithrombin Concentrate in Patients with Sepsis-Induced Disseminated Intravascular Coagulation. | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | disseminated intravascular coagulation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | thrombocytopenia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anticoagulants | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | antithrombins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | thrombomodulin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | infections | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MURAO, Atsushi
× MURAO, Atsushi× KATO, Takayuki× YAMANE, Tetsunobu× HONDA, Goichi× EGUCHI, Yutaka |
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著者別名 |
村尾, 淳司
× 村尾, 淳司× 加藤, 隆之× 山根, 哲信× 江口, 豊 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Thrombomodulin alfa (TM-α, recombinant human soluble thrombomodulin) and antithrombin (AT) concentrate are anticoagulant agents for the treatment of disseminated intravascular coagulation (DIC). A post hoc analysis using data from 1198 patients with infection-induced DIC from the post-marketing surveillance of TM-α was conducted. To identify subgroups that benefit from combination therapy, the patients were a priori stratified into four groups by a platelet (Plt) count of 50 × 103/μL and plasma AT level of 50% (groups 1, 2, 3, and 4, with high Plt/high AT, high Plt/low AT, low Plt/high AT, and low Plt/low AT, respectively). Kaplan-Meier survival analysis showed significantly worse survival in groups 2 and 4 had than in group 1 (p = 0.0480, p < 0.0001, respectively), and multivariate analysis showed that concomitant AT concentrate was independently correlated with reduced 28-day mortality only in group 4 (hazard ratio 0.6193; 95% confidence interval, 0.3912-0.9805). The adverse drug reactions (ADRs) and bleeding ADRs were not different among the groups. Patients with both severe thrombocytopenia and AT deficiency are candidates for combined anticoagulant therapy with TM-α and AT concentrate. | |||||
書誌情報 |
en : Clinical and Applied Thrombosis/Hemostasis 巻 28, 発行日 2022-02-15 |
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出版者 | ||||||
出版者 | SAGE | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1938-2723 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35166576 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8851499/ | |||||
関連名称 | PMC8851499 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1177/10760296221077096 | |||||
関連名称 | 10.1177/10760296221077096 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2022 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |