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High incidence of major bleeding with off-label use of edoxaban
http://hdl.handle.net/10422/00013149
http://hdl.handle.net/10422/00013149b1337dac-8a0f-4273-8159-c107ddab624c
名前 / ファイル | ライセンス | アクション |
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jcbn.21-9 (275.6 kB)
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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-30 | |||||
タイトル | ||||||
タイトル | High incidence of major bleeding with off-label use of edoxaban | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | direct oral anticoagulants | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | edoxaban | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anticoagulants | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | off-label | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bleeding | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
FUKUI, Rika
× FUKUI, Rika× HIRA, Daiki× KUNITSU, Yuki× ISONO, Tetsuichiro× TABUCHI, Yohei× IKUNO, Yoshihiro× UESHIMA, Satoshi× ITOH, Hideki× TANAKA, Toshihiro× TERADA, Tomohiro |
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著者別名 |
福井, 里佳
× 福井, 里佳× 寺田, 智祐× 平, 大樹× 國津, 侑貴× 磯野, 哲一郎× 田淵, 陽平× 生野, 芳博× 伊藤, 英樹× 田中, 俊宏 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In clinical practice, edoxaban is sometimes prescribed for off-label use based on the hypothesis that it is as safe and effective as warfarin. However, there is limited safety information on off-label use due to lack of clinical trial. We aimed to analyze the tolerability of off-label use of edoxaban and to identify patient characteristics associated with major bleeding as adverse effects. Patients under edoxaban treatment between January 2017 and December 2017 were enrolled in this retrospective cohort study. The incidence of major bleeding with off-label use compared with on-label use was analyzed using by log-rank test. Univariate and multivariate regression analysis were undertaken to detect independent variables with significant odds ratio that associated with major bleeding. After the exclusion criteria were applied, the patients were divided into two groups: off-label group (n = 30) and on-label group (n = 161). Incidence of major bleeding was found to be higher in the off-label group (13.3%) than in the on-label group (3.7%) (p<0.05). Multivariate adjustment showed that the off-label use or portal vein thrombosis and patients with history of major bleeding has significantly higher incidence of major bleeding. We demonstrated that off-label use of edoxaban may be a significant risk factor for major bleeding. | |||||
書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 巻 69, 号 3, p. 311-316, 発行日 2021-11-01 |
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出版者 | ||||||
出版者 | 一般社団法人 日本酸化ストレス学会 | |||||
別言語の出版者 | ||||||
出版者 | SOCIETY FOR FREE RADICAL RESEARCH JAPAN | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0912-0009 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3164/jcbn.21-9 | |||||
関連名称 | 10.3164/jcbn.21-9 | |||||
権利 | ||||||
権利情報 | © 2021 JCBN | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
NAID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 130008110266 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |