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The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals.
http://hdl.handle.net/10422/00013081
http://hdl.handle.net/10422/00013081a4fce5b4-1f4e-4e22-9d6f-cf7f848d5e2d
名前 / ファイル | ライセンス | アクション |
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journal.pone.0140427 (554.6 kB)
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2021-09-22 | |||||||||||
タイトル | ||||||||||||
タイトル | The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals. | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Weight gain | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Body weight | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Genetic polymorphism | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Body mass index | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Obesity | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Overweight | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Type 2 diabetes | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Dyslipidemia | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
NISHIOJI, Kenichi
× NISHIOJI, Kenichi× MOCHIZUKI, Naomi× KOBAYASHI, Masao× KAMAGUCHI, Mai× SUMIDA, Yoshio× NISHIMURA, Takeshi× YAMAGUCHI, Kanji× 角谷, 寛
WEKO
6474
× ITOH, Yoshito |
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著者別名 |
角谷, 寛
× 角谷, 寛
WEKO
6474
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Non-alcoholic fatty liver disease (NAFLD) in non-obese individuals is inadequately elucidated. We aim to investigate the impact of known genetic polymorphisms on NAFLD and the interaction between genetic risks and weight gain on NAFLD in obese and non-obese Japanese individuals. A total of 1164 participants who received health checkups were included. Participants with excessive alcohol consumption, with viral hepatitis or other inappropriate cases were excluded. Fatty liver was diagnosed by ultrasonography. Participants with a body mass index (BMI) of <18.5 kg/m2, 18.5-22.9 kg/m2, 23.0-24.9 kg/m2 and ≥25 kg/m2 were classified underweight, normal weight, overweight and obese, respectively. Self-administered questionnaire for lifestyle was assessed and a total of 8 previously reported genetic polymorphisms were chosen and examined. In all, 824 subjects were enrolled. The overall prevalence of NAFLD was 33.0%: 0% in underweight, 15.3% in normal weight, 41.1% in overweight and 71.7% in obese individuals. The prevalence of NAFLD is more affected by the G allele of patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 in normal weight (odds ratio (OR) 3.52; 95%-CI: 1.42-8.71; P = 0.0063) and in overweight individuals (OR 2.60; 95%-CI: 1.14-5.91; P = 0.0225) than in obese individuals (not significant). Moreover, the G allele of PNPLA3 rs738409 and weight gain ≥10 kg after age 20 had a joint effect on the risk of NAFLD in the normal weight (OR 12.00; 95% CI: 3.71-38.79; P = 3.3×10-5) and the overweight individuals (OR 13.40; 95% CI: 2.92-61.36; P = 0.0008). The G allele of PNPLA3 rs738409 is a prominent risk factor for NAFLD and the interaction between the PNPLA3 rs738409 and weight gain ≥10 kg after age 20 plays a crucial role in the pathogenesis of NAFLD, especially in non-obese Japanese individuals. | |||||||||||
書誌情報 |
en : PLoS ONE 巻 10, 号 10, 発行日 2015-10-20 |
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出版者 | ||||||||||||
出版者 | Public Library of Science | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 1932-6203 | |||||||||||
PMID | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 26485523 | |||||||||||
PMCID | ||||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4617644/ | |||||||||||
関連名称 | PMC4617644 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.1371/journal.pone.0140427 | |||||||||||
関連名称 | 10.1371/journal.pone.0140427 | |||||||||||
権利 | ||||||||||||
権利情報 | © 2015 Nishioji et al. | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | ||||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
資源タイプ | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | Journal Article |