WEKO3
-
RootNode
アイテム
Mucosa-associated gut microbiome in Japanese patients with functional constipation.
http://hdl.handle.net/10422/00012939
http://hdl.handle.net/10422/00012939f6cf77d0-509d-46c1-8969-d6e23e86144c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jcbn.20-93 (597.8 kB)
|
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-07 | |||||
| タイトル | ||||||
| タイトル | Mucosa-associated gut microbiome in Japanese patients with functional constipation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | microbiota | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | constipation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | butyrate | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SUGITANI, Yoshihiko
× SUGITANI, Yoshihiko× INOUE, Ryo× INATOMI, Osamu× NISHIDA, Atsushi× MORISHIMA, So× IMAI, Takayuki× KAWAHARA, Masahiro× NAITO, Yuji× ANDOH, Akira |
|||||
| 著者別名 |
杉谷, 義彦
× 杉谷, 義彦× 稲富, 理× 西田, 淳史× 今井, 隆行× 河原, 真大× 安藤, 朗 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The number of patients with chronic constipation is increasing in Japan. We investigated the gut mucosa-associated microbiome in Japanese patients with functional constipation. Diagnosis was made according to the Rome IV criteria. Mucosal samples were obtained by gentle brushing of mucosa surfaces. The gut microbiome was analyzed using 16S rRNA gene sequencing. There were no significant differences in bacteria α-diversity such as richness and evenness. The PCoA indicated significant structural differences between the constipation group and healthy controls (p = 0.017 for unweighted and p = 0.027 for weighted). The abundance of the phylum Bacteroidetes was significantly higher in the constipation group. The abundance of the genera Streptococcus, Fusobacterium, Comamonas, and Alistipes was significantly higher in the constipation group. The abundance of the genera Acinetobacter, Oscillospilla, Mucispirillum, Propinibacterium, and Anaerotruncus was significantly lower in the constipation group. In the constipation group, the proportion of genes responsible for sulfur metabolism, selenocompound metabolism, sulfur relay system was significantly higher and the proportion of d-arginine and d-ornithine metabolism and flavonoid biosynthesis was significantly lower. In conclusion, we identified differences of the mucosa-associated microbiome between Japanese patients with functional constipation and healthy controls. The mucosa-associated microbiome of functional constipation was characterized by higher levels of Bacteroidetes (Alistipes). | |||||
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 巻 68, 号 2, p. 187-192, 発行日 2021 |
|||||
| 出版者 | ||||||
| 出版者 | 一般社団法人 日本酸化ストレス学会 | |||||
| 別言語の出版者 | ||||||
| 出版者 | SOCIETY FOR FREE RADICAL RESEARCH JAPAN | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3164/jcbn.20-93 | |||||
| 関連名称 | 10.3164/jcbn.20-93 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 JCBN | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| NAID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 130007993416 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
