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A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study.
http://hdl.handle.net/10422/00012931
http://hdl.handle.net/10422/00012931b8f64578-0aeb-4088-9c03-dc4128590598
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S0007114521000684 (704.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-18 | |||||
| タイトル | ||||||
| タイトル | A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | alcohol intake confounding | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | aldehyde dehydrogenase 2 (ALDH2) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | genome-wide association study | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | sweet food consumption | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SUZUKI, Taro
× SUZUKI, Taro× NAKAMURA, Yasuyuki× DOI, Yukiko× NARITA, Akira× SHIMIZU, Atsushi× IMAEDA, Nahomi× GOTO, Chiho× MATSUI, Kenji× KADOTA, Aya× MIURA, Katsuyuki× NAKATOCHI, Masahiro× TANAKA, Keitaro× HARA, Megumi× IKEZAKI, Hiroaki× MURATA, Masayuki× TAKEZAKI, Toshiro× NISHIMOTO, Daisaku× Matsuo, Keitaro× OZE, Isao× KURIYAMA, Nagato× OZAKI, Etsuko× MIKAMI, Haruo× NAKAMURA, Yohko× WATANABE, Miki× SUZUKI, Sadao× KATSUURA-KAMANO, Sakurako× ARISAWA, Kokichi× KURIKI, Kiyonori× Momozawa, Yukihide× Kubo, Michiaki× TAKEUCHI, Kenji× KITA, Yoshikuni× WAKAI, Kenji |
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| 著者別名 |
中村, 保幸
× 中村, 保幸× 門田, 文× 三浦, 克之× 喜多, 義邦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social, or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analyzed GWAS data on sweets consumption using 14,073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with sweets consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1 to 3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/day) in addition to the above-described variables. We found 418 single nucleotide polymorphisms (SNPs) located in 12q24 that were associated with sweets consumption. SNPs with the 10 lowest P-values were located on nine genes including at the BRAP, ACAD10, and ALDH2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with sweets intake with genome-wide significance. In conclusion, we found a significant number of SNPs located on 12q24 genes that were associated with sweets intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake. | |||||
| 書誌情報 |
en : The British journal of nutrition p. 1-37, 発行日 2021-02-26 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1475-2662 | |||||
| PMID | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33632354 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1017/s0007114521000684 | |||||
| 関連名称 | 10.1017/S0007114521000684 | |||||
| 権利 | ||||||
| 権利情報 | © The Authors 2021 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
