WEKO3
アイテム
{"_buckets": {"deposit": "b5c60a70-2ef6-4864-98ff-6d4fecd59ffc"}, "_deposit": {"created_by": 11, "id": "3767", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3767"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003767", "sets": ["203"]}, "author_link": ["8312", "534", "12", "8313", "531", "8314", "7935", "7179", "550"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-11-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicVolumeNumber": "23", "bibliographic_titles": [{}, {"bibliographic_title": "iScience", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "寺島, 智也"}], "nameIdentifiers": [{"nameIdentifier": "534", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40378485", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40378485"}, {"nameIdentifier": "0000-0001-9050-7101", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-9050-7101"}]}, {"creatorNames": [{"creatorName": "小橋, 修平"}], "nameIdentifiers": [{"nameIdentifier": "7935", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樫, 美和子"}], "nameIdentifiers": [{"nameIdentifier": "550", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40732459", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40732459"}]}, {"creatorNames": [{"creatorName": "大橋, 夏子"}], "nameIdentifiers": [{"nameIdentifier": "7179", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60816776", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60816776"}]}, {"creatorNames": [{"creatorName": "小島, 秀人"}], "nameIdentifiers": [{"nameIdentifier": "531", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00225434", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00225434"}, {"nameIdentifier": "0000-0002-4781-2052", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-4781-2052"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Several treatments have been attempted in amyotrophic lateral sclerosis (ALS) animal models and patients. Recently, transplantation of bone marrow-derived mononuclear cells (MNCs) was investigated as a regenerative therapy for ALS, but satisfactory treatments remain to be established. To develop an effective treatment, we focused on mesenchymal stem cells (MSCs) expressing hepatocyte growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor using human artificial chromosome vector (HAC-MSCs). Here, we demonstrated the transplantation of MNCs with HAC-MSCs in ALS mice. As per our results, the progression of motor dysfunction was significantly delayed, and their survival was prolonged dramatically. Additional analysis revealed preservation of motor neurons, suppression of gliosis, engraftment of numerous MNCs, and elevated chemotaxis-related cytokines in the spinal cord of treated mice. Therefore, growth factor-expressing MSCs enhance the therapeutic effects of bone marrow-derived MNCs for ALS and have a high potential as a novel cell therapy for patients with ALS. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier Inc."}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "33251493", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.isci.2020.101764"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.isci.2020.101764", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_13": {"attribute_name": "PMCID", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PMC7677706"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7677706/", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2020 The Author(s). "}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "25890042", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "TERASHIMA, Tomoya"}], "nameIdentifiers": [{"nameIdentifier": "534", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40378485", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40378485"}, {"nameIdentifier": "0000-0001-9050-7101", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-9050-7101"}]}, {"creatorNames": [{"creatorName": "Kushima, Ryoji"}], "nameIdentifiers": [{"nameIdentifier": "12", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40252382", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40252382"}]}, {"creatorNames": [{"creatorName": "WATANABE, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "8312", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKANISHI, Mami"}], "nameIdentifiers": [{"nameIdentifier": "8313", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HONDA, Naoto"}], "nameIdentifiers": [{"nameIdentifier": "8314", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KATAGI, Miwako"}], "nameIdentifiers": [{"nameIdentifier": "550", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40732459", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40732459"}]}, {"creatorNames": [{"creatorName": "OHASHI, Natsuko"}], "nameIdentifiers": [{"nameIdentifier": "7179", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60816776", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60816776"}]}, {"creatorNames": [{"creatorName": "KOJIMA, Hideto"}], "nameIdentifiers": [{"nameIdentifier": "531", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00225434", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00225434"}, {"nameIdentifier": "0000-0002-4781-2052", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-4781-2052"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "j.isci.2020.101764.pdf", "filesize": [{"value": "6.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "licensetype": "license_free", "mimetype": "application/pdf", "size": 6400000.0, "url": {"label": "j.isci.2020.101764", "url": "https://shiga-med.repo.nii.ac.jp/record/3767/files/j.isci.2020.101764.pdf"}, "version_id": "36d79247-0e2f-44f7-88b1-a75830976b7f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Cellular Neuroscience", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Molecular Neuroscience", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Stem Cells Research", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice."}]}, "item_type_id": "4", "owner": "11", "path": ["203"], "permalink_uri": "http://hdl.handle.net/10422/00012877", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-12-23"}, "publish_date": "2020-12-23", "publish_status": "0", "recid": "3767", "relation": {}, "relation_version_is_last": true, "title": ["Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice."], "weko_shared_id": -1}
Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice.
http://hdl.handle.net/10422/00012877
http://hdl.handle.net/10422/000128773c49be21-6d13-448d-9733-9b8aaa2e07d5
名前 / ファイル | ライセンス | アクション |
---|---|---|
j.isci.2020.101764 (6.4 MB)
|
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-12-23 | |||||
タイトル | ||||||
タイトル | Enhancing the Therapeutic Efficacy of Bone Marrow-Derived Mononuclear Cells with Growth Factor-Expressing Mesenchymal Stem Cells for ALS in Mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cellular Neuroscience | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Molecular Neuroscience | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Stem Cells Research | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TERASHIMA, Tomoya
× TERASHIMA, Tomoya× Kushima, Ryoji× WATANABE, Yasuhiro× NAKANISHI, Mami× HONDA, Naoto× KATAGI, Miwako× OHASHI, Natsuko× KOJIMA, Hideto |
|||||
著者別名 |
寺島, 智也
× 寺島, 智也× 小橋, 修平× 樫, 美和子× 大橋, 夏子× 小島, 秀人 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several treatments have been attempted in amyotrophic lateral sclerosis (ALS) animal models and patients. Recently, transplantation of bone marrow-derived mononuclear cells (MNCs) was investigated as a regenerative therapy for ALS, but satisfactory treatments remain to be established. To develop an effective treatment, we focused on mesenchymal stem cells (MSCs) expressing hepatocyte growth factor, glial cell line-derived neurotrophic factor, and insulin-like growth factor using human artificial chromosome vector (HAC-MSCs). Here, we demonstrated the transplantation of MNCs with HAC-MSCs in ALS mice. As per our results, the progression of motor dysfunction was significantly delayed, and their survival was prolonged dramatically. Additional analysis revealed preservation of motor neurons, suppression of gliosis, engraftment of numerous MNCs, and elevated chemotaxis-related cytokines in the spinal cord of treated mice. Therefore, growth factor-expressing MSCs enhance the therapeutic effects of bone marrow-derived MNCs for ALS and have a high potential as a novel cell therapy for patients with ALS. | |||||
書誌情報 |
en : iScience 巻 23, 号 11, 発行日 2020-11-04 |
|||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 25890042 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 33251493 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7677706/ | |||||
関連名称 | PMC7677706 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.isci.2020.101764 | |||||
関連名称 | 10.1016/j.isci.2020.101764 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |