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Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.
http://hdl.handle.net/10422/00012765
http://hdl.handle.net/10422/0001276532939063-b602-49b5-bc2d-d683ebad0f5b
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-27 | |||||
タイトル | ||||||
タイトル | Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Heart | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ectodomain shedding | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nardilysin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | p75NTR | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sympathetic nerve | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
OHNO, Mikiko
× OHNO, Mikiko× NISHI, Kiyoto× HIRAOKA, Yoshinori× NIIZUMA, Shinichiro× MATSUDA, Shintaro× IWASAKI, Hirotaka× KIMURA, Takeshi× NISHI, Eiichiro |
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著者別名 |
大野, 美紀子
× 大野, 美紀子× 岩崎, 広高× 西, 英一郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cardiac sympathetic innervation is critically involved in the regulation of circulatory dynamics. However, the molecular mechanism for the innervation patterning has remained elusive. Here, we demonstrate that nardilysin (NRDC, Nrdc), an enhancer of ectodomain shedding, regulates cardiac sympathetic innervation. Nardilysin-deficient (Nrdc-/- ) mice show hypoplastic hearts, hypotension, bradycardia, and abnormal sympathetic innervation patterning. While the innervation of left ventricle (LV) of wild-type mice is denser in the subepicardium than in the subendocardium, Nrdc-/- LV lacks such a polarity and is uniformly and more abundantly innervated. At the molecular level, the full-length form of p75 neurotrophin receptor (p75NTR , Ngfr) is increased in Nrdc-/- LV due to the reduced ectodomain shedding of p75NTR . Importantly, the reduction of p75NTR rescued the abnormal innervation phenotype of Nrdc-/- mice. Moreover, sympathetic neuron-specific, but not cardiomyocyte-specific deletion of Nrdc recapitulated the abnormal innervation patterning of Nrdc-/- mice. In conclusion, neuronal nardilysin critically regulates cardiac sympathetic innervation and circulatory dynamics via modulation of p75NTR . | |||||
書誌情報 |
en : FASEB journal : official publication of the Federation of American Societies for Experimental Biology 発行日 2020-07-19 |
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出版者 | ||||||
出版者 | Wiley | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1530-6860 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32683751 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1096/fj.202000604r | |||||
関連名称 | 10.1096/fj.202000604R | |||||
権利 | ||||||
権利情報 | © 2020 Federation of American Societies for Experimental Biology. | |||||
目次 | ||||||
内容記述タイプ | Other | |||||
内容記述 | . | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |