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Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model.
http://hdl.handle.net/10422/00012751
http://hdl.handle.net/10422/0001275149687e45-9793-4685-aa97-268a073ec7e2
名前 / ファイル | ライセンス | アクション |
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AAC.02561-19 (3.1 MB)
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© 2020 American Society for Microbiology.
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AAC.02561-19_SupplementalMaterials (2.0 MB)
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© 2020 American Society for Microbiology.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-08 | |||||
タイトル | ||||||
タイトル | Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NGUYEN, Cong Thanh
× NGUYEN, Cong Thanh× SUZUKI, Saori× ITOH, Yasushi× ISHIGAKI, Hirohito× NAKAYAMA, Misako× HAYASHI, Kaori× MATSUNO, Keita× OKAMATSU, Masatoshi× SAKODA, Yoshihiro× KIDA, Hiroshi× OGASAWARA, Kazumasa |
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著者別名 |
鈴木, 紗織
× 鈴木, 紗織× 伊藤, 靖× 石垣, 宏仁× 仲山, 美沙子× 林, 香里× 小笠原, 一誠 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Attention has been paid to H5N6 highly pathogenic avian influenza virus (HPAIV) because of its heavy burden on the poultry industry and human mortality. Since an influenza A virus carrying N6 neuraminidase (NA) has never spread in humans, the potential for H5N6 HPAIV to cause disease in humans and the efficacy of antiviral drugs against the virus need to be urgently assessed. We used nonhuman primates to elucidate the pathogenesis of H5N6 HPAIV as well as to determine the efficacy of antiviral drugs against the virus. H5N6 HPAIV infection led to high fever in cynomolgus macaques. The lung injury caused by the virus was severe, with diffuse alveolar damage and neutrophil infiltration. In addition, an increase in interferon alpha (IFN-α) showed an inverse correlation with virus titers during the infection process. Oseltamivir was effective for reducing H5N6 HPAIV propagation, and continuous treatment with peramivir reduced virus propagation and the severity of symptoms in the early stage. This study also showed pathologically severe lung injury states in cynomolgus macaques infected with H5N6 HPAIV, even in those that received early antiviral drug treatments, indicating the need for close monitoring and further studies on virus pathogenicity and new antiviral therapies. | |||||
書誌情報 |
en : Antimicrobial agents and chemotherapy 巻 64, 号 7, 発行日 2020-06-23 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1098-6596 | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 32284377 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1128/aac.02561-19 | |||||
関連名称 | 10.1128/AAC.02561-19 | |||||
権利 | ||||||
権利情報 | © 2020 American Society for Microbiology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |