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Proteinuria and Reduced Estimated Glomerular Filtration Rate Are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study.
http://hdl.handle.net/10422/00012731
http://hdl.handle.net/10422/00012731f5a878dc-db72-40c6-b125-f766177a74db
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jea.JE20180258 (595.1 kB)
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This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-06-23 | |||||
| タイトル | ||||||
| タイトル | Proteinuria and Reduced Estimated Glomerular Filtration Rate Are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | chronic kidney disease (CKD) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cognitive function | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | estimated glomerular filtration rate | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | proteinuria. | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
FUJIYOSHI, Akira
× FUJIYOSHI, Akira× MIURA, Katsuyuki× OHKUBO, Takayoshi× MIYAGAWA, Naoko× SAITO, Yoshino× MIYAZAWA, Itsuko× SHIINO, Akihiko× KADOTA, Aya× KADOWAKI, Sayaka× HISAMATSU, Takashi× TORII, Sayuki× TAKASHIMA, Naoyuki× TOOYAMA, Ikuo× UESHIMA, Hirotsugu |
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| 著者別名 |
藤吉, 朗
× 藤吉, 朗× 三浦, 克之× 大久保, 孝義× 宮川, 尚子× 齋藤, 祥乃× 宮澤, 伊都子× 椎野, 顯彦× 門田, 文× 門脇, 紗也佳× 久松, 隆史× 鳥居, さゆ希× 高嶋, 直敬× 遠山, 育夫× 上島, 弘嗣 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Methods: Our cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up (higher CASI scores [range 0 to 100] indicate better cognition). Proteinuria was assessed via dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m2) or by proteinuria (no, trace, and positive), considered normal, moderate, and advanced, respectively. Using linear regression, we computed mean CASI score, with simultaneous adjustment for proteinuria and eGFR in addition to other potential confounders. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Results: Significant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (Ptrend = 0.029), and 90.0, 88.5, and 88.5 for eGFR (Ptrend = 0.015) in mutual-adjustment model. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Conclusions: Proteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline. |
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| 書誌情報 |
en : Journal of Epidemiology 巻 30, 号 6, p. 244-252, 発行日 2020-06-05 |
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| 出版者 | ||||||
| 出版者 | Japan Epidemiological Association | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0917-5040 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31130560 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7217691/ | |||||
| 関連名称 | PMC7217691 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.2188/jea.je20180258 | |||||
| 関連名称 | 10.2188/jea.JE20180258 | |||||
| 権利 | ||||||
| 権利情報 | © 2019 Akira Fujiyoshi et al. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
