WEKO3
アイテム
{"_buckets": {"deposit": "760fc03b-fe36-4447-bc02-e5088dede13b"}, "_deposit": {"created_by": 11, "id": "3599", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3599"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003599", "sets": ["193"]}, "author_link": ["3728", "7955", "7953", "7957", "7958", "7954", "7956", "7959"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "2198", "bibliographicPageStart": "2184", "bibliographicVolumeNumber": "37", "bibliographic_titles": [{}, {"bibliographic_title": "Advances in therapy", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "大路, 正人"}], "nameIdentifiers": [{"nameIdentifier": "3728", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252650 ", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252650 "}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Purpose: \nTo compare visual outcomes and treatment burden between intravitreally administered aflibercept (IVT-AFL) and ranibizumab (RBZ) treat-and-extend (T\u0026E) regimens in patients with wet age-related macular degeneration (wAMD) at 2 years. ", "subitem_description_type": "Abstract"}, {"subitem_description": "Methods:\nA systematic literature review was carried out in Medline, EMBASE, and CENTRAL in October 2018. Matching-adjusted indirect comparison (MAIC) and/or individual patient data meta-regression was used to connect ALTAIR (assessing IVT-AFL T\u0026E) with other studies, adjusting for between-trial differences in baseline visual acuity and age or baseline visual acuity, age, and polypoidal choroidal vasculopathy (PCV) status. Sensitivity analyses were conducted to test the robustness of the results, including direct MAIC between IVT-AFL T\u0026E (ALTAIR) and RBZ T\u0026E (CANTREAT and TREX-AMD trials). ", "subitem_description_type": "Abstract"}, {"subitem_description": "Results: \nSix randomized controlled trials (RCTs) (ALTAIR, VIEW 1 and 2, CATT, CANTREAT, and TREX) were included in the analysis. IVT-AFL T\u0026E was assessed in one study, ALTAIR (n = 255), while RBZ T\u0026E was assessed in two trials (n = 327). At 2 years, the median difference (95% credibility interval) between IVT-AFL T\u0026E and RBZ T\u0026E regarding the numbers of Early Treatment Diabetic Retinopathy Study (ETDRS) letters gained was not significant (M1: - 2.29 [- 8.10, 3.58]; M2: - 0.55 [- 6.34, 5.29]). IVT-AFL T\u0026E was associated with significantly fewer injections than RBZ-T\u0026E (M1: - 6.12 [- 7.60, - 4.65]; M2: - 5.93 [- 7.42, - 4.45]). Results of the sensitivity analyses were consistent with the main scenarios.", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusion: \nPatients with wAMD receiving an IVT-AFL T\u0026E regimen achieved and maintained improvement in visual acuity with fewer injections over 2 years compared with RBZ T\u0026E. IVT-AFL T\u0026E may therefore serve as the optimal therapy for wAMD, as it was associated with clinical efficacy and minimized treatment burden. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Nature"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "32222903", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s12325-020-01298-x "}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s12325-020-01298-x", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "©The Author(s) 2020"}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1865-8652", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OHJI, Masahito"}], "nameIdentifiers": [{"nameIdentifier": "3728", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90252650 ", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90252650 "}]}, {"creatorNames": [{"creatorName": "LANZETTA, Paolo"}], "nameIdentifiers": [{"nameIdentifier": "7953", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOROBELNIK, Jean-Francois"}], "nameIdentifiers": [{"nameIdentifier": "7954", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WOJCIECHOWSKI , Piotr"}], "nameIdentifiers": [{"nameIdentifier": "7955", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAIEB, Vanessa"}], "nameIdentifiers": [{"nameIdentifier": "7956", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "DESCHASEAUX, Celine"}], "nameIdentifiers": [{"nameIdentifier": "7957", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "JANER, Daniel "}], "nameIdentifiers": [{"nameIdentifier": "7958", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TUCKMANTEL, Claudia"}], "nameIdentifiers": [{"nameIdentifier": "7959", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "s12325-020-01298-x.pdf", "filesize": [{"value": "725.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article\u0027s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article\u0027s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.", "licensetype": "license_free", "mimetype": "application/pdf", "size": 725700.0, "url": {"label": "s12325-020-01298-x", "url": "https://shiga-med.repo.nii.ac.jp/record/3599/files/s12325-020-01298-x.pdf"}, "version_id": "208becb6-62a7-48b4-b2b5-176bda7631b2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Intravitreal anti-vascular endothelial growth factor therapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Network meta-analysis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ophthalmology", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Wet age-related macular degeneration", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Efficacy and Treatment Burden of Intravitreal Aflibercept Versus Intravitreal Ranibizumab Treat-and-Extend Regimens at 2 Years: Network Meta-Analysis Incorporating Individual Patient Data Meta-Regression and Matching-Adjusted Indirect Comparison.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Efficacy and Treatment Burden of Intravitreal Aflibercept Versus Intravitreal Ranibizumab Treat-and-Extend Regimens at 2 Years: Network Meta-Analysis Incorporating Individual Patient Data Meta-Regression and Matching-Adjusted Indirect Comparison."}]}, "item_type_id": "4", "owner": "11", "path": ["193"], "permalink_uri": "http://hdl.handle.net/10422/00012717", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-06-17"}, "publish_date": "2020-06-17", "publish_status": "0", "recid": "3599", "relation": {}, "relation_version_is_last": true, "title": ["Efficacy and Treatment Burden of Intravitreal Aflibercept Versus Intravitreal Ranibizumab Treat-and-Extend Regimens at 2 Years: Network Meta-Analysis Incorporating Individual Patient Data Meta-Regression and Matching-Adjusted Indirect Comparison."], "weko_shared_id": -1}
Efficacy and Treatment Burden of Intravitreal Aflibercept Versus Intravitreal Ranibizumab Treat-and-Extend Regimens at 2 Years: Network Meta-Analysis Incorporating Individual Patient Data Meta-Regression and Matching-Adjusted Indirect Comparison.
http://hdl.handle.net/10422/00012717
http://hdl.handle.net/10422/000127178c76c94f-8ce2-4ad2-a1e5-379e4994de7e
名前 / ファイル | ライセンス | アクション |
---|---|---|
s12325-020-01298-x (725.7 kB)
|
This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-17 | |||||
タイトル | ||||||
タイトル | Efficacy and Treatment Burden of Intravitreal Aflibercept Versus Intravitreal Ranibizumab Treat-and-Extend Regimens at 2 Years: Network Meta-Analysis Incorporating Individual Patient Data Meta-Regression and Matching-Adjusted Indirect Comparison. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Intravitreal anti-vascular endothelial growth factor therapy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Network meta-analysis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ophthalmology | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Wet age-related macular degeneration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
OHJI, Masahito
× OHJI, Masahito× LANZETTA, Paolo× KOROBELNIK, Jean-Francois× WOJCIECHOWSKI , Piotr× TAIEB, Vanessa× DESCHASEAUX, Celine× JANER, Daniel× TUCKMANTEL, Claudia |
|||||
著者別名 |
大路, 正人
× 大路, 正人 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To compare visual outcomes and treatment burden between intravitreally administered aflibercept (IVT-AFL) and ranibizumab (RBZ) treat-and-extend (T&E) regimens in patients with wet age-related macular degeneration (wAMD) at 2 years. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: A systematic literature review was carried out in Medline, EMBASE, and CENTRAL in October 2018. Matching-adjusted indirect comparison (MAIC) and/or individual patient data meta-regression was used to connect ALTAIR (assessing IVT-AFL T&E) with other studies, adjusting for between-trial differences in baseline visual acuity and age or baseline visual acuity, age, and polypoidal choroidal vasculopathy (PCV) status. Sensitivity analyses were conducted to test the robustness of the results, including direct MAIC between IVT-AFL T&E (ALTAIR) and RBZ T&E (CANTREAT and TREX-AMD trials). |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Six randomized controlled trials (RCTs) (ALTAIR, VIEW 1 and 2, CATT, CANTREAT, and TREX) were included in the analysis. IVT-AFL T&E was assessed in one study, ALTAIR (n = 255), while RBZ T&E was assessed in two trials (n = 327). At 2 years, the median difference (95% credibility interval) between IVT-AFL T&E and RBZ T&E regarding the numbers of Early Treatment Diabetic Retinopathy Study (ETDRS) letters gained was not significant (M1: - 2.29 [- 8.10, 3.58]; M2: - 0.55 [- 6.34, 5.29]). IVT-AFL T&E was associated with significantly fewer injections than RBZ-T&E (M1: - 6.12 [- 7.60, - 4.65]; M2: - 5.93 [- 7.42, - 4.45]). Results of the sensitivity analyses were consistent with the main scenarios. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: Patients with wAMD receiving an IVT-AFL T&E regimen achieved and maintained improvement in visual acuity with fewer injections over 2 years compared with RBZ T&E. IVT-AFL T&E may therefore serve as the optimal therapy for wAMD, as it was associated with clinical efficacy and minimized treatment burden. |
|||||
書誌情報 |
en : Advances in therapy 巻 37, 号 5, p. 2184-2198, 発行日 2020-05 |
|||||
出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1865-8652 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 32222903 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s12325-020-01298-x | |||||
関連名称 | 10.1007/s12325-020-01298-x | |||||
権利 | ||||||
権利情報 | ©The Author(s) 2020 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |