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Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
http://hdl.handle.net/10422/00012674
http://hdl.handle.net/10422/000126740eca761c-033b-4408-bcab-d5053564de32
名前 / ファイル | ライセンス | アクション |
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j.antiviral.2020.104790 (6.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-05-19 | |||||
タイトル | ||||||
タイトル | Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | H7N9 avian influenza virus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neuraminidase inhibitor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Nonhuman primates | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Resistance | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Reverse genetics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Revertant | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SUZUKI, Saori
× SUZUKI, Saori× SHICHINOHE, Shintaro× ITOH, Yasushi× NAKAYAMA, Misako× ISHIGAKI, Hirohito× MORI, Yuya× Ogata-Nakahara, Ayako× NGUYEN, Cong Thanh× OKAMATSU, Masatoshi× SAKODA, Yoshihiro× KIDA, Hiroshi× OGASAWARA, Kazumasa |
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著者別名 |
鈴木, 紗織
× 鈴木, 紗織× 七戸, 新太郎× 仲山, 美沙子× 石垣, 宏仁× 森, 優也× 小笠原, 一誠 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human cases of H7N9 influenza A virus infection have been increasing since 2013. The first choice of treatment for influenza is neuraminidase (NA) inhibitors (NAIs), but there is a concern that NAI-resistant viruses are selected in the presence of NAIs. In our previous study, an H7N9 virus carrying AA substitution of threonine (T) for isoleucine (I) at residue 222 in NA (NA222T, N2 numbering) and an H7N9 virus carrying AA substitution of lysine (K) for arginine (R) at residue 292 in NA (NA292K, N2 numbering) were found in different macaques that had been infected with A/Anhui/1/2013 (H7N9) and treated with NAIs. In the present study, the variant with NA292K showed not only resistance to NAIs but also lower replication activity in MDCK cells than did the virus with wild-type NA, whereas the variant with NA222T, which was less resistant to NAIs, showed replication activity similar to that of the wild-type virus. Next, we examined the pathogenicity of these H7N9 NAI-resistant viruses in macaques. The variants caused clinical signs similar to those caused by the wild-type virus with similar replication potency. However, the virus with NA292K was replaced within 7 days by that with NA292R (same as the wild-type) in nasal samples from macaques infected with the virus with NA292K, i.e. the so-called revertant (wild-type virus) became dominant in the population in the absence of an NAI. These results suggest that the clinical signs observed in macaques infected with the NA292K virus are caused by the NA292K virus and the NA292R virus and that the virus with NA292K may not replicate continuously in the upper respiratory tract of patients without treatment as effectively as the wild-type virus. | |||||
書誌情報 |
en : Antiviral research 巻 178, p. 104790, 発行日 2020-04-06 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1872-9096 | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 32272175 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.antiviral.2020.104790 | |||||
関連名称 | 10.1016/j.antiviral.2020.104790 | |||||
権利 | ||||||
権利情報 | © 2020 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |