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High Prevalence of Late-Appearing T-Wave in Patients With Long QT Syndrome Type 8.
http://hdl.handle.net/10422/00012646
http://hdl.handle.net/10422/000126466021e49a-ebb0-456c-89ce-702f9dcd4ec2
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-04-21 | |||||
タイトル | ||||||
タイトル | High Prevalence of Late-Appearing T-Wave in Patients With Long QT Syndrome Type 8. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Genetics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | LQT8 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Late-appearing T-wave | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Long QT syndrome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | T-wave morphology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
FUKUYAMA, Megumi
× FUKUYAMA, Megumi× OHNO, Seiko× OZAWA, Junichi× KATO, Koichi× MAKIYAMA, Takeru× NAKAGAWA, Yoshihisa× HORIE, Minoru |
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著者別名 |
福山, 恵
× 福山, 恵× 大野, 聖子× 加藤, 浩一× 中川, 義久× 堀江, 稔 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Long QT syndrome type 8 (LQT8) is a rare genotype of long QT syndrome. Late-appearing T-waves (LaT) are often documented in patients with LQT8, as in long QT syndrome type 3 (LQT3); however, the frequency of LaT and its relevance to the clinical severity of LQT8 remains unclear. This study investigated T-wave morphology (TWM) in LQT3 and LQT8 patients and compared the phenotypes of different TWMs.Methods and Results:TWMs were classified into 3 types: early onset T-waves (EoT), LaT, and bifid T-waves (biT). Electrocardiogram (ECG) measurements, symptoms, and topology were compared among TWM types. The study cohort comprised 25 patients with LQT8 (14 mutations) and 25 patients with LQT3 (14 mutations). LaT was detected in 17 (68%) and 13 (52%) LQT8 and LQT3 patients, respectively. There were no significant differences in ECG measurements or the severity of symptoms between patients with LaT and those with other TWMs in either the LQT8 or LQT3 group. However, only patients with LaT experienced cardiopulmonary arrest. Compared with the LQT3 group, in the LQT8 group there was a tendency for mutations in patients with LaT to be located in domain-linking regions. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | CONCLUSIONS: In this study, two-thirds of patients with LQT8 exhibited LaT on ECG, and nearly one-third of those experienced cardiopulmonary arrest. Further investigations are warranted to differentiate between LQT3 and LQT8 in patients exhibiting LaT to optimize therapy. |
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書誌情報 |
en : Circulation journal : official journal of the Japanese Circulation Society 巻 84, 号 4, p. 559-568, 発行日 2020-03-25 |
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出版者 | ||||||
出版者 | 日本循環器学会 | |||||
別言語の出版者 | ||||||
出版者 | Japanese Circulation Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-4820 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32161207 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1253/circj.CJ-19-1101 | |||||
関連名称 | 10.1253/circj.CJ-19-1101 | |||||
権利 | ||||||
権利情報 | © 2020 THE JAPANESE CIRCULATION SOCIETY | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |