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Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study.
http://hdl.handle.net/10422/00012639
http://hdl.handle.net/10422/0001263925c050e9-86e9-48f1-a29d-3ddb723b3c59
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
jea.JE20180193 (597.1 kB)
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© 2019 Ziyi Liu et al.
This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-09 | |||||
| タイトル | ||||||
| タイトル | Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cognitive abilities screening instrument (CASI) | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cognitive function | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | diabetes mellitus | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | fasting blood glucose | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
LIU, Ziyi
× LIU, Ziyi× ZAID, Maryam× HISAMATSU, Takashi× Tanaka-Mizuno, Sachiko× FUJIYOSHI, Akira× MIYAGAWA, Naoko× ITO, Takahiro× KADOTA, Aya× TOOYAMA, Ikuo× MIURA, Katsuyuki× UESHIMA, Hirotsugu |
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| 著者別名 |
久松, 隆史
× 久松, 隆史× 田中, 佐智子× 藤吉, 朗× 宮川, 尚子× 伊藤, 隆洋× 門田, 文× 遠山, 育夫× 三浦, 克之× 上島, 弘嗣 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men. |
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| 書誌情報 |
en : Journal of epidemiology 巻 30, 号 3, p. 121-127, 発行日 2020-03-05 |
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| 出版者 | ||||||
| 出版者 | Japan Epidemiological Association | |||||
| 別言語の出版者 | ||||||
| 出版者 | 日本疫学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1349-9092 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31130559 | |||||
| PMCID | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025918/ | |||||
| 関連名称 | PMC7025918 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.2188/jea.JE20180193 | |||||
| 関連名称 | 10.2188/jea.JE20180193 | |||||
| 権利 | ||||||
| 権利情報 | © 2019 Ziyi Liu et al. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
