WEKO3
-
RootNode
アイテム
Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.
http://hdl.handle.net/10422/00012636
http://hdl.handle.net/10422/000126361b665a20-59e9-4666-9750-69e33f4ee17e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
j.bbrc.2020.02.088 (6.5 MB)
|
© 2020 Elsevier Inc. All rights reserved.
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-07 | |||||
| タイトル | ||||||
| タイトル | Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Autophagy | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Diabetic kidney disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Massive proteinuria | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Mitochondria | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Podocytes | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
YOSHIBAYASHI, Mamoru
× YOSHIBAYASHI, Mamoru× KUME, Shinji× YASUDA-YAMAHARA, Mako× YAMAHARA, Kosuke× TAKEDA, Naoko× OSAWA, Norihisa× Chin-Kanasaki, Masami× Nakae, Yuki× YOKOI, Hideki× MUKOYAMA, Masashi× ASANUMA, Katsuhiko× MAEGAWA, Hiroshi× ARAKI, Shin-ichi |
|||||
| 著者別名 |
吉林, 護
× 吉林, 護× 久米, 真司× 山原, 真子× 山原, 康佑× 武田, 尚子× 大澤, 紀之× 金崎, 雅美× 中江, 由希× 前川, 聡× 荒木, 信一 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To examine the cell-protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes, we analyzed the renal phenotype of tamoxifen (TM)-inducible podocyte-specific Atg5-deficient (iPodo-Atg5-/-) mice with experimental endothelial dysfunction. In both control and iPodo-Atg5-/- mice, high fat diet (HFD) feeding induced glomerular endothelial damage characterized by decreased urinary nitric oxide (NO) excretion, collapsed endothelial fenestrae, and reduced endothelial glycocalyx. HFD-fed control mice showed slight albuminuria and nearly normal podocyte morphology. In contrast, HFD-fed iPodo-Atg5-/- mice developed massive albuminuria accompanied by severe podocyte injury that was observed predominantly in podocytes adjacent to damaged endothelial cells by scanning electron microscopy. Although podocyte-specific autophagy deficiency did not affect endothelial NO synthase deficiency-associated albuminuria, it markedly exacerbated albuminuria and severe podocyte morphological damage when the damage was induced by intravenous neuraminidase injection to remove glycocalyx from the endothelial surface. Furthermore, endoplasmic reticulum stress was accelerated in podocytes of iPodo-Atg5-/- mice stimulated with neuraminidase, and treatment with molecular chaperone tauroursodeoxycholic acid improved neuraminidase-induced severe albuminuria and podocyte injury. In conclusion, podocyte autophagy plays a renoprotective role against diabetes-related structural endothelial damage, providing an additional insight into the pathogenesis of massive proteinuria in diabetic nephropathy. | |||||
| 書誌情報 |
en : Biochemical and biophysical research communications 巻 525, 号 2, p. 319-325, 発行日 2020-04-30 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1090-2104 | |||||
| PMID | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32089264 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2020.02.088 | |||||
| 関連名称 | 10.1016/j.bbrc.2020.02.088 | |||||
| 権利 | ||||||
| 権利情報 | © 2020 Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
