WEKO3
アイテム
{"_buckets": {"deposit": "5bd0126b-b913-447e-8d41-337c55884303"}, "_deposit": {"created_by": 11, "id": "3499", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3499"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003499", "sets": ["251"]}, "author_link": ["7769", "7770", "5888", "7771", "7768", "117"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01-29", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}, {"bibliographic_title": "Frontiers in neuroscience", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "渕上, 孝裕"}], "nameIdentifiers": [{"nameIdentifier": "7769", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小山, なつ"}], "nameIdentifiers": [{"nameIdentifier": "117", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50135464", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50135464"}]}, {"creatorNames": [{"creatorName": "等, 誠司"}], "nameIdentifiers": [{"nameIdentifier": "5888", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70300895", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70300895"}, {"nameIdentifier": "0000-0002-6339-6802", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-6339-6802"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Early life stress can exert detrimental or beneficial effects on neural development and postnatal behavior depending on the timing, duration, strength, and ability to control the stressors. In this study, we utilized a maternal and social deprivation (MSD) model to investigate the effects of early life stress on neural stem cells (NSCs) and neurogenesis in the adult brain. We found that MSD during the stress-hyporesponsive period (SHRP) (early-MSD), when corticosterone secretion is suppressed, increased the size of the NSC population, whereas the same stress beyond the SHRP abrogated these effects. Early-MSD enhanced neurogenesis not only in the dentate gyrus of the hippocampus, one of the classic neurogenic regions, but also in the amygdala. In addition, mice exposed to early-MSD exhibited a reduction in amygdala/hippocampus-dependent fear memory. These results suggest that animals exposed to early life stress during the SHRP have reinforced stress resilience to cope with perceived stressors to maintain a normal homeostatic state.", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Frontiers Research Foundation"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "32063832", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3389/fnins.2020.00022"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3389/fnins.2020.00022", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": " © 2020 Daun, Fuchigami, Koyama, Maruta, Ikenaka and Hitoshi."}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "DAUN, Kenny Anak"}], "nameIdentifiers": [{"nameIdentifier": "7768", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUCHIGAMI, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "7769", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOYAMA, Natsu"}], "nameIdentifiers": [{"nameIdentifier": "117", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50135464", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50135464"}]}, {"creatorNames": [{"creatorName": "MARUTA, Noriko"}], "nameIdentifiers": [{"nameIdentifier": "7770", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IKENAKA, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "7771", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HITOSHI, Seiji"}], "nameIdentifiers": [{"nameIdentifier": "5888", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70300895", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=70300895"}, {"nameIdentifier": "0000-0002-6339-6802", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0002-6339-6802"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-02-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "fnins.2020.00022.pdf", "filesize": [{"value": "4.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.", "licensetype": "license_free", "mimetype": "application/pdf", "size": 4900000.0, "url": {"label": "fnins.2020.00022", "url": "https://shiga-med.repo.nii.ac.jp/record/3499/files/fnins.2020.00022.pdf"}, "version_id": "5473b0f3-3572-40b1-abb1-beacb5f50398"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "amygdala", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "corticosterone", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fear memory", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neural stem cell", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "resilience", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "stress", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory."}]}, "item_type_id": "4", "owner": "11", "path": ["251"], "permalink_uri": "http://hdl.handle.net/10422/00012622", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-02-26"}, "publish_date": "2020-02-26", "publish_status": "0", "recid": "3499", "relation": {}, "relation_version_is_last": true, "title": ["Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory."], "weko_shared_id": -1}
Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory.
http://hdl.handle.net/10422/00012622
http://hdl.handle.net/10422/00012622d10c66a5-609c-4a58-8ecf-f0358b8f8b05
名前 / ファイル | ライセンス | アクション |
---|---|---|
fnins.2020.00022 (4.9 MB)
|
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-02-26 | |||||
タイトル | ||||||
タイトル | Early Maternal and Social Deprivation Expands Neural Stem Cell Population Size and Reduces Hippocampus/Amygdala-Dependent Fear Memory. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | amygdala | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | corticosterone | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fear memory | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neural stem cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | resilience | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | stress | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
DAUN, Kenny Anak
× DAUN, Kenny Anak× FUCHIGAMI, Takahiro× KOYAMA, Natsu× MARUTA, Noriko× IKENAKA, Kazuhiro× HITOSHI, Seiji |
|||||
著者別名 |
渕上, 孝裕
× 渕上, 孝裕× 小山, なつ× 等, 誠司 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Early life stress can exert detrimental or beneficial effects on neural development and postnatal behavior depending on the timing, duration, strength, and ability to control the stressors. In this study, we utilized a maternal and social deprivation (MSD) model to investigate the effects of early life stress on neural stem cells (NSCs) and neurogenesis in the adult brain. We found that MSD during the stress-hyporesponsive period (SHRP) (early-MSD), when corticosterone secretion is suppressed, increased the size of the NSC population, whereas the same stress beyond the SHRP abrogated these effects. Early-MSD enhanced neurogenesis not only in the dentate gyrus of the hippocampus, one of the classic neurogenic regions, but also in the amygdala. In addition, mice exposed to early-MSD exhibited a reduction in amygdala/hippocampus-dependent fear memory. These results suggest that animals exposed to early life stress during the SHRP have reinforced stress resilience to cope with perceived stressors to maintain a normal homeostatic state. | |||||
書誌情報 |
en : Frontiers in neuroscience 発行日 2020-01-29 |
|||||
出版者 | ||||||
出版者 | Frontiers Research Foundation | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 32063832 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3389/fnins.2020.00022 | |||||
関連名称 | 10.3389/fnins.2020.00022 | |||||
権利 | ||||||
権利情報 | © 2020 Daun, Fuchigami, Koyama, Maruta, Ikenaka and Hitoshi. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |