WEKO3
アイテム
{"_buckets": {"deposit": "e912ebb4-58ad-434d-931d-43a6321cc5de"}, "_deposit": {"created_by": 11, "id": "3455", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "3455"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00003455", "sets": ["35"]}, "author_link": ["7630", "7626", "7628", "7629", "1957", "7242", "7627", "7631", "7552"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-10-29", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "246", "bibliographicPageStart": "229", "bibliographicVolumeNumber": "72", "bibliographic_titles": [{}, {"bibliographic_title": "Journal of Alzheimer\u0027s Disease", "bibliographic_titleLang": "en"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "柳沢, 大治郎 "}], "nameIdentifiers": [{"nameIdentifier": "7626", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50581112", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50581112"}]}, {"creatorNames": [{"creatorName": "遠山, 育夫"}], "nameIdentifiers": [{"nameIdentifier": "1957", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20207533", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20207533"}, {"nameIdentifier": "0000-0001-8054-9666", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8054-9666"}]}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We previously\ndemonstrated that supplementation with TRF improved cognitive function and modulated amyloid pathology in AβPP/PS1 mice brains. The current study was designed to examine proteomic profiles underlying the therapeutic effect of TRF in the brain. Proteomic analyses were performed on samples of hippocampus, medial prefrontal cortex (mPFC), and striatum using liquid chromatography coupled to Q Exactive HF Orbitrap mass spectrometry. From these analyses, we profiled a total of 5,847 proteins of which 155 proteins were differentially expressed between AβPP/PS1 and wild-type mice. TRF supplementation of these mice altered the expression of 255 proteins in the hippocampus, mPFC, and striatum. TRF also negatively modulated the expression of amyloid beta A4 protein and receptor-type tyrosine-protein phosphatase alpha protein in the hippocampus. The expression of proteins in metabolic\npathways, oxidative phosphorylation, and those involved in Alzheimer\u0027s disease were altered in the brains of AβPP/PS1 mice that received TRF supplementation.", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "IOS Press"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "31594216", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.3233/JAD-181171"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3233/JAD-181171", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2019 – IOS Press and the authors. All rights reserved"}]}, "item_4_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1387-2877", "subitem_source_identifier_type": "ISSN"}]}, "item_4_source_id_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11545428", "subitem_source_identifier_type": "NCID"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hamezah, Hamizah Shahirah Binti"}], "nameIdentifiers": [{"nameIdentifier": "7552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Durani, Lina Wati Binti"}], "nameIdentifiers": [{"nameIdentifier": "7242", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YANAGISAWA, Daijiro"}], "nameIdentifiers": [{"nameIdentifier": "7626", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50581112", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50581112"}]}, {"creatorNames": [{"creatorName": "Ibrahim, Nor Faeizah"}], "nameIdentifiers": [{"nameIdentifier": "7627", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "0000-0001-7041-4688", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-7041-4688"}]}, {"creatorNames": [{"creatorName": "Aizat, Wan Mohd"}], "nameIdentifiers": [{"nameIdentifier": "7628", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Makpol, Suzana"}], "nameIdentifiers": [{"nameIdentifier": "7629", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wan Ngah, Wan Zurinah"}], "nameIdentifiers": [{"nameIdentifier": "7630", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Damanhur, Hanafi Ahmad"}], "nameIdentifiers": [{"nameIdentifier": "7631", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TOOYAMA, Ikuo"}], "nameIdentifiers": [{"nameIdentifier": "1957", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20207533", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20207533"}, {"nameIdentifier": "0000-0001-8054-9666", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8054-9666"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-11-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JAD-181171.pdf", "filesize": [{"value": "748.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2019 – IOS Press and the authors. All rights reserved\nThis article is published online with Open Access and distributed under the terms \nof the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).", "licensetype": "license_free", "mimetype": "application/pdf", "size": 748200.0, "url": {"label": "JAD-181171", "url": "https://shiga-med.repo.nii.ac.jp/record/3455/files/JAD-181171.pdf"}, "version_id": "dae9aa3a-ab6b-40f2-8a2c-8b70fd3f8c48"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-11-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "Supplementary Materials.zip", "filesize": [{"value": "12.4 MB"}], "format": "application/x-zip-compressed", "future_date_message": "", "is_thumbnail": false, "licensefree": "© 2019 – IOS Press and the authors. All rights reserved\nThis article is published online with Open Access and distributed under the terms \nof the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).", "licensetype": "license_free", "mimetype": "application/x-zip-compressed", "size": 12400000.0, "url": {"label": "Supplementary Materials", "url": "https://shiga-med.repo.nii.ac.jp/record/3455/files/Supplementary Materials.zip"}, "version_id": "9c4b5b3c-0635-4e7b-b2f5-7d9735b46e1f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Alzheimer’s disease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LC-MS", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "palm oil", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "proteomics", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tocotrienol", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction."}]}, "item_type_id": "4", "owner": "11", "path": ["35"], "permalink_uri": "http://hdl.handle.net/10422/00012578", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-11-25"}, "publish_date": "2019-11-25", "publish_status": "0", "recid": "3455", "relation": {}, "relation_version_is_last": true, "title": ["Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction."], "weko_shared_id": -1}
Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.
http://hdl.handle.net/10422/00012578
http://hdl.handle.net/10422/00012578ff013c55-0897-4bd6-90c1-bf338bcc7030
名前 / ファイル | ライセンス | アクション |
---|---|---|
JAD-181171 (748.2 kB)
|
© 2019 – IOS Press and the authors. All rights reserved
This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). |
|
Supplementary Materials (12.4 MB)
|
© 2019 – IOS Press and the authors. All rights reserved
This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-11-25 | |||||
タイトル | ||||||
タイトル | Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Alzheimer’s disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | LC-MS | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | palm oil | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | proteomics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tocotrienol | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hamezah, Hamizah Shahirah Binti
× Hamezah, Hamizah Shahirah Binti× Durani, Lina Wati Binti× YANAGISAWA, Daijiro× Ibrahim, Nor Faeizah× Aizat, Wan Mohd× Makpol, Suzana× Wan Ngah, Wan Zurinah× Damanhur, Hanafi Ahmad× TOOYAMA, Ikuo |
|||||
著者別名 |
柳沢, 大治郎
× 柳沢, 大治郎× 遠山, 育夫 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We previously demonstrated that supplementation with TRF improved cognitive function and modulated amyloid pathology in AβPP/PS1 mice brains. The current study was designed to examine proteomic profiles underlying the therapeutic effect of TRF in the brain. Proteomic analyses were performed on samples of hippocampus, medial prefrontal cortex (mPFC), and striatum using liquid chromatography coupled to Q Exactive HF Orbitrap mass spectrometry. From these analyses, we profiled a total of 5,847 proteins of which 155 proteins were differentially expressed between AβPP/PS1 and wild-type mice. TRF supplementation of these mice altered the expression of 255 proteins in the hippocampus, mPFC, and striatum. TRF also negatively modulated the expression of amyloid beta A4 protein and receptor-type tyrosine-protein phosphatase alpha protein in the hippocampus. The expression of proteins in metabolic pathways, oxidative phosphorylation, and those involved in Alzheimer's disease were altered in the brains of AβPP/PS1 mice that received TRF supplementation. |
|||||
書誌情報 |
en : Journal of Alzheimer's Disease 巻 72, 号 1, p. 229-246, 発行日 2019-10-29 |
|||||
出版者 | ||||||
出版者 | IOS Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1387-2877 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11545428 | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 31594216 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3233/JAD-181171 | |||||
関連名称 | 10.3233/JAD-181171 | |||||
権利 | ||||||
権利情報 | © 2019 – IOS Press and the authors. All rights reserved | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |