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Rapidly and Slowly Growing Lineages in Chromosomal Instability-Type Gland-Forming Gastric Carcinomas as Revealed by Multisampling Analysis of DNA Copy-Number Profile.
http://hdl.handle.net/10422/00012483
http://hdl.handle.net/10422/00012483cf9c1785-8689-4a7a-9a98-bd8b3c23f9e5
名前 / ファイル | ライセンス | アクション |
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10.1159000494926 (999.3 kB)
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All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-02-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Rapidly and Slowly Growing Lineages in Chromosomal Instability-Type Gland-Forming Gastric Carcinomas as Revealed by Multisampling Analysis of DNA Copy-Number Profile. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Stomach | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Adenocarcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chromosomal instability | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Copy-number alterations | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Array-based comparative genomic hybridization | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Metastasis risk | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Duong, Tu Thanh
× Duong, Tu Thanh× Vo, Thi Ngoc Diem× NAKAYAMA, Takahisa× MUKAISHO, Ken-ichi× BAMBA, Masamichi× Nguyen, Trung Sao× SUGIHARA, Hiroyuki |
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著者別名 |
仲山, 貴永
× 仲山, 貴永× 向所, 賢一× 馬場, 正道× 杉原, 洋行 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND:To examine whether gastric carcinoma (GC) with chromosomal instability (CIN-type GC), the largest category in the Cancer Genome Atlas classification, consists of a single genetic lineage, we conducted a multisampling analysis of genomic DNA copy-number profile. METHODS:We performed array-based comparative genomic hybridization using formalin-fixed paraffin-embedded tissues from 54 gland-forming GCs containing a total of 106 DNA samples from mucosal, extramucosal invasive, and lymph node lesions. Microarray data were analyzed by unsupervised hierarchical clustering and penetrance plots. Epstein-Barr virus infection status and mismatch repair(MMR) enzyme-silencing/p53/mucin expression were examined by in situ hybridization and immunohistochemistry, respectively. RESULTS:The samples examined were divided into gain-rich cluster A and loss-rich cluster B, which were different in tumor locus and patient age. The T1/T2-4 ratio, the frequency of small cancers (diameter 2-4 cm), and<unterline></unterline> intestinal mucin expression were higher in cluster B than in cluster A, but there were no significant differences in the frequencies of MMR silencing, mutant p53 pattern, and lymph node metastasis between the 2 clusters. CONCLUSIONS:We demonstrated that CIN-type GC could be categorized into 2 genetic lineages which are different in terms of rapidity of local extension but similar in terms of nodal metastasis risk. |
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言語 | en | |||||
書誌情報 |
en : Pathobiology 巻 83, 号 2-3, p. 118-127, 発行日 2019-01-09 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Karger | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1423-0291 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30625481 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1159/000494926 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2019 S. Karger AG, Basel. | |||||
権利 | ||||||
権利情報 | All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |