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Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion.
http://hdl.handle.net/10422/00012477
http://hdl.handle.net/10422/00012477dd556e13-e685-4781-a369-6d66ce993ca0
名前 / ファイル | ライセンス | アクション |
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OPTH.S46817.pdf (386.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-12-06 | |||||
タイトル | ||||||
タイトル | Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aqueous humor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | branch retinal vein occlusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macular edema | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fujikawa, Masato
× Fujikawa, Masato× SAWADA, Osamu× Miyake, Taichiro× KAKINOKI, Masashi× 澤田, 智子× KAWAMURA, Hajime× OHJI, Masahito |
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著者別名 |
藤川, 正人
× 藤川, 正人× 澤田, 修× 三宅, 太一郎× 柿木, 雅志× 澤田, 智子× 川村, 肇× 大路, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine the role of vascular endothelial growth factor (VEGF) in macular edema secondary to branch retinal vein occlusion (BRVO). Aqueous humor samples were collected from 52 eyes with macular edema secondary to BRVO before intravitreal drug injections and from 62 control eyes with cataract. VEGF was measured using an enzyme-linked immunosorbent assay. Fluorescein angiography showed capillary nonperfused areas (NPAs). Macular edema was evaluated by optical coherence tomography as the central retinal thickness. The mean aqueous VEGF levels in eyes with BRVO and control eyes with cataract were, respectively, 290.5 pg/mL ± 294.9 pg/mL (range 81.9 pg/mL-1567.3 pg/mL) and 118.0 pg/mL ± 50.1 pg/mL (range 24.6 pg/mL-241.1 pg/mL), which differed significantly (P < 0.0001). The mean VEGF level in eyes with BRVO without apparent NPA was 171.4 pg/mL ± 52.5 pg/mL (range 90.9 pg/mL-299.9 pg/mL), which was significantly higher than controls (P = 0.001). VEGF levels were correlated positively with the size of NPA (P = 0.0002) but not with the central retinal thickness. The aqueous VEGF concentration in patients with macular edema secondary to BRVO increased significantly and was correlated significantly with the size of NPA. Aqueous VEGF increased even in eyes without apparent NPA. |
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書誌情報 |
Clinical Ophthalmology 巻 7, p. 1497-1501, 発行日 2013-12 |
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出版者 | ||||||
出版者 | Dove Medical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1177-5467 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 23901258 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/OPTH.S46817 | |||||
権利 | ||||||
権利情報 | ©2013 Fujikawa et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |