WEKO3
アイテム
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Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.
http://hdl.handle.net/10422/00012459
http://hdl.handle.net/10422/0001245966e73d58-da93-4d80-a28e-a94865d97e44
名前 / ファイル | ライセンス | アクション |
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sciadv.1602663 (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2018-11-05 | |||||||||||
タイトル | ||||||||||||
タイトル | Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Animals | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Astrocytes | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Biological Clocks | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Brain | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Drosophila melanogaster | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Fatty Acid-Binding Protein 7 | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Female | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Humans | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Male | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Mice | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Mice, Knockout | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Mutation, Missense | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Signal Transduction | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Sleep | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Tumor Suppressor Proteins | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
Gerstner, Jason R
× Gerstner, Jason R× Perron, Isaac J× Riedy, Samantha M× Yoshikawa, Takeo× 角谷, 寛
WEKO
6474
× Owada, Yuji× Van Dongen, Hans PA× Galante, Raymond J× Dickinson, Kaitlin× Yin, Jerry CP× Pack, Allan I× Frank, Marcos G |
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著者別名 |
角谷, 寛
× 角谷, 寛
WEKO
6474
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle. However, the role of FABP7 in regulating sleep remains poorly understood. We found that the missense mutation FABP7.T61M is associated with fragmented sleep in humans. This phenotype was recapitulated in mice and fruitflies bearing similar mutations: Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes also show fragmented sleep. These results provide novel evidence for a distinct molecular pathway linking lipid-signaling cascades within astrocytes in sleep regulation among phylogenetically disparate species. | |||||||||||
書誌情報 |
Science Advances 巻 3, 号 4, p. e1602663, 発行日 2017-04-05 |
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出版者 | ||||||||||||
出版者 | American Association for the Advancement of Science | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 2375-2548 | |||||||||||
PMID | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 28435883 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1126/sciadv.1602663 | |||||||||||
権利 | ||||||||||||
権利情報 | 2017© The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
資源タイプ | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | Journal Article |