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Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes.
http://hdl.handle.net/10422/00012432
http://hdl.handle.net/10422/000124320652bbfc-251d-4f71-ac8a-3220feb9e77c
| 名前 / ファイル | ライセンス | アクション |
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s41598-018-21445-3 (3.6 MB)
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Supplementary Information (4.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-09-14 | |||||
| タイトル | ||||||
| タイトル | Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Jam, Faidruz Azura
× Jam, Faidruz Azura× Kadota, Yosuke× Mendsaikhan, Anarmaa× Tooyama, Ikuo× MORI, Masaki |
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| 著者別名 |
門田, 陽介
× 門田, 陽介× 遠山, 育夫× 森, 雅樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Young individuals possess distinct properties that adults do not. The juvenile animals show higher activities for growth, healing, learning and plasticity than adults. The machinery for establishing these juvenile properties is not fully understood. To better understand the molecular constituents for the above properties, we performed a comprehensive transcriptome analysis of differently aged cells of mice by high-throughput sequencing and identified the genes selectively highly expressed in the young cells. These genes, collectively called as juvenility-associated genes (JAGs), show significant enrichments in the functions such as alternative splicing, phosphorylation and extracellular matrix (ECM). This implies the juvenescence might be achieved by these functions at the cell level. The JAG mutations are associated with progeria syndromes and growth disorders. Thus, the JAGs might organize the juvenile property of young animals and analysis of JAGs may provide scientific and therapeutic approaches toward treating the genetic diseases. | |||||
| 書誌情報 |
Scientific Reports 巻 8, 号 1, p. 3132, 発行日 2018-02-15 |
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| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29449671 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-018-21445-3 | |||||
| 権利 | ||||||
| 権利情報 | ©The Author(s) 2018 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
