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Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.
http://hdl.handle.net/10422/00012369
http://hdl.handle.net/10422/000123695a1e26dc-1ca2-4878-aa55-b09a5968b63c
名前 / ファイル | ライセンス | アクション |
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© 2017 The Author(s). This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-23 | |||||
タイトル | ||||||
タイトル | Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α-synuclein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oligodendrocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oligodendrocyte precursor cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | primary cell culture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multiple system atrophy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | synucleinopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glial cytoplasmic inclusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neurotrophic factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | misfolding | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autophagy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kaji, Seiji
× Kaji, Seiji× Maki, Takakuni× Kinoshita, Hisanori× Uemura, Norihito× Ayaki, Takashi× Kawamoto, Yasuhiro× Furuta, Takahiro× URUSHITANI, Makoto× Hasegawa, Masato× Kinoshita, Yusuke× Ono, Yuichi× Mao, Xiaobo× Quach, Tran H× Iwai, Kazuhiro× Dawson, Valina L× Dawson, Ted M× Takahashi, Ryosuke |
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著者別名 |
漆谷, 真
× 漆谷, 真 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Glial cytoplasmic inclusions (GCIs), commonly observed as α-synuclein (α-syn)-positive aggregates within oligodendrocytes, are the pathological hallmark of multiple system atrophy. The origin of α-syn in GCIs is uncertain; there is little evidence of endogenous α-syn expression in oligodendrocyte lineage cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes (OLGs). Here, based on in vitro analysis using primary rat cell cultures, we elucidated that preformed fibrils (PFFs) generated from recombinant human α-syn trigger multimerization and an upsurge of endogenous α-syn in OPCs, which is attributable to insufficient autophagic proteolysis. RNA-seq analysis of OPCs revealed that α-syn PFFs interfered with the expression of proteins associated with neuromodulation and myelination. Furthermore, we detected cytoplasmic α-syn inclusions in OLGs through differentiation of OPCs pre-incubated with PFFs. Overall, our findings suggest the possibility of endogenous α-syn accumulation in OPCs that contributes to GCI formation and perturbation of neuronal/glial support in multiple system atrophy brains. |
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書誌情報 |
Stem Cell Reports 巻 10, 号 2, p. 356-365, 発行日 2018-01-11 |
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出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2213-6711 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 29337114 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.stemcr.2017.12.001 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |