WEKO3
アイテム
{"_buckets": {"deposit": "9ecc8c6e-19ec-4115-a791-bd4bf45c094d"}, "_deposit": {"created_by": 3, "id": "1279", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1279"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00001279", "sets": ["220"]}, "author_link": ["2568", "6523", "2579", "2575", "2545", "1957"], "item_4_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "28", "bibliographicPageStart": "21", "bibliographicVolumeNumber": "123", "bibliographic_titles": [{"bibliographic_title": "Journal of Neurochemistry"}]}]}, "item_4_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "西村, 正樹"}], "nameIdentifiers": [{"nameIdentifier": "2545", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40322739", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40322739"}]}, {"creatorNames": [{"creatorName": "中村, 紳一郎"}], "nameIdentifiers": [{"nameIdentifier": "6523", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50307980", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50307980"}]}, {"creatorNames": [{"creatorName": "遠山, 育夫"}], "nameIdentifiers": [{"nameIdentifier": "1957", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20207533", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20207533"}, {"nameIdentifier": "0000-0001-8054-9666", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8054-9666"}]}]}, "item_4_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "pdf", "subitem_description_type": "Other"}]}, "item_4_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Age-dependent accumulation of the amyloid-β peptide (Aβ) in the brain is a pre-condition for development of Alzheimer\u0027s disease. A relative increase in the generation of longer Aβ species such as Aβ42 and Aβ43 is critical for Aβ deposition, but the underlying mechanism remains unresolved. Here, we performed a cell-free assay using microsome fractions of temporal cortex tissues from 42 cynomolgus monkeys and found that Aβ40-generating γ-secretase activity (γ40) decreased with age, whereas Aβ42-generating γ-secretase activity (γ42) was unaltered. In ELISAs, more than 80% of monkeys over 20-years old showed evidence of Aβ accumulation in the temporal cortex. The ratio of γ42 to γ40 increased with age and correlated with the level of accumulated Aβ. These results suggest that γ-secretase activity undergoes age-related, non-genetic modulation and that this modulation may cause Aβ accumulation in aging brains. Similar modulation may predispose aged human brains to Alzheimer\u0027s disease. ", "subitem_description_type": "Abstract"}]}, "item_4_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Journal Article", "subitem_description_type": "Other"}]}, "item_4_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley-Blackwell"}]}, "item_4_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "22817324", "subitem_relation_type_select": "PMID"}}]}, "item_4_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/j.1471-4159.2012.07884.x"}], "subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/j.1471-4159.2012.07884.x", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2012 The Authors. Journal of Neurochemistry"}, {"subitem_rights": "© 2012 International Society for Neurochemistry"}]}, "item_4_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NISHIMURA, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "2545", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40322739", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=40322739"}]}, {"creatorNames": [{"creatorName": "NAKAMURA, Shinichiro"}], "nameIdentifiers": [{"nameIdentifier": "6523", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50307980", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50307980"}]}, {"creatorNames": [{"creatorName": "KIMURA, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "2579", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "LIU, Lei"}], "nameIdentifiers": [{"nameIdentifier": "2575", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SUZUKI, Toshiharu"}], "nameIdentifiers": [{"nameIdentifier": "2568", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TOOYAMA, Ikuo"}], "nameIdentifiers": [{"nameIdentifier": "1957", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20207533", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20207533"}, {"nameIdentifier": "0000-0001-8054-9666", "nameIdentifierScheme": "ORCID", "nameIdentifierURI": "https://orcid.org/0000-0001-8054-9666"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "j.1471-4159.2012.07884.x.pdf", "filesize": [{"value": "4.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4500000.0, "url": {"label": "j.1471-4159.2012.07884.x.pdf", "url": "https://shiga-med.repo.nii.ac.jp/record/1279/files/j.1471-4159.2012.07884.x.pdf"}, "version_id": "d6558ac8-74c3-44ce-ae54-07d4570da989"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Age-related modulation of γ-secretase activity in non-human primate brains.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Age-related modulation of γ-secretase activity in non-human primate brains."}]}, "item_type_id": "4", "owner": "3", "path": ["220"], "permalink_uri": "http://hdl.handle.net/10422/2997", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-03-19"}, "publish_date": "2013-03-19", "publish_status": "0", "recid": "1279", "relation": {}, "relation_version_is_last": true, "title": ["Age-related modulation of γ-secretase activity in non-human primate brains."], "weko_shared_id": 3}
Age-related modulation of γ-secretase activity in non-human primate brains.
http://hdl.handle.net/10422/2997
http://hdl.handle.net/10422/299770bb7375-448b-40f2-aaf7-ba2bda088d54
名前 / ファイル | ライセンス | アクション |
---|---|---|
j.1471-4159.2012.07884.x.pdf (4.5 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-03-19 | |||||
タイトル | ||||||
タイトル | Age-related modulation of γ-secretase activity in non-human primate brains. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NISHIMURA, Masaki
× NISHIMURA, Masaki× NAKAMURA, Shinichiro× KIMURA, Nobuyuki× LIU, Lei× SUZUKI, Toshiharu× TOOYAMA, Ikuo |
|||||
著者別名 |
西村, 正樹
× 西村, 正樹× 中村, 紳一郎× 遠山, 育夫 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Age-dependent accumulation of the amyloid-β peptide (Aβ) in the brain is a pre-condition for development of Alzheimer's disease. A relative increase in the generation of longer Aβ species such as Aβ42 and Aβ43 is critical for Aβ deposition, but the underlying mechanism remains unresolved. Here, we performed a cell-free assay using microsome fractions of temporal cortex tissues from 42 cynomolgus monkeys and found that Aβ40-generating γ-secretase activity (γ40) decreased with age, whereas Aβ42-generating γ-secretase activity (γ42) was unaltered. In ELISAs, more than 80% of monkeys over 20-years old showed evidence of Aβ accumulation in the temporal cortex. The ratio of γ42 to γ40 increased with age and correlated with the level of accumulated Aβ. These results suggest that γ-secretase activity undergoes age-related, non-genetic modulation and that this modulation may cause Aβ accumulation in aging brains. Similar modulation may predispose aged human brains to Alzheimer's disease. | |||||
書誌情報 |
Journal of Neurochemistry 巻 123, 号 1, p. 21-28, 発行日 2012-10 |
|||||
出版者 | ||||||
出版者 | Wiley-Blackwell | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 22817324 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/j.1471-4159.2012.07884.x | |||||
関連名称 | 10.1111/j.1471-4159.2012.07884.x | |||||
権利 | ||||||
権利情報 | © 2012 The Authors. Journal of Neurochemistry | |||||
権利 | ||||||
権利情報 | © 2012 International Society for Neurochemistry | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |