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Assessment of mouse VEGF neutralization by ranibizumab and aflibercept
http://hdl.handle.net/10422/00013490
http://hdl.handle.net/10422/000134909d0f0bd4-b969-4915-89a2-f5878864bca3
名前 / ファイル | ライセンス | アクション |
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journal.pone.0278951 (2.6 MB)
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-01-25 | |||||
タイトル | ||||||
タイトル | Assessment of mouse VEGF neutralization by ranibizumab and aflibercept | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
ICHIYAMA, Yusuke
× ICHIYAMA, Yusuke× MATSUMOTO, Riko× OBATA, Shumpei× SAWADA, Osamu× SAISHIN, Yoshitsugu× KAKINOKI, Masashi× SAWADA, Tomoko× OHJI, Masahito |
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著者別名 |
一山, 悠介
× 一山, 悠介× 松本, 理子× 小幡, 峻平× 澤田, 修× 西信, 良嗣× 柿木, 雅志× 澤田, 智子× 大路, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To assess the interaction between ranibizumab, aflibercept, and mouse vascular endothelial growth factor (VEGF), both in vivo and in vitro. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: In vivo, the effect of intravitreal injection of ranibizumab and aflibercept on oxygen induced retinopathy (OIR) and the effect of multiple intraperitoneal injections of ranibizumab and aflibercept on neonatal mice were assessed. In vitro, the interaction of mouse VEGF-A with aflibercept or ranibizumab as the primary antibody was analyzed by Western blot. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: In both experiments using intravitreal injections in OIR mice and multiple intraperitoneal injections in neonatal mice, anti-VEGF effects were observed with aflibercept, but not with ranibizumab. Western blot analysis showed immunoreactive bands for mouse VEGF-A in the aflibercept-probed blot, but not in the ranibizumab-probed blot. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusions: Aflibercept but not ranibizumab interacts with mouse VEGF, both in vivo and in vitro. When conducting experiments using anti-VEGF drugs in mice, aflibercept is suitable, but ranibizumab is not. |
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書誌情報 |
en : PLoS ONE 巻 17, 号 12, 発行日 2022-12-21 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 36542626 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9770341/ | |||||
関連名称 | PMC9770341 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1371/journal.pone.0278951 | |||||
関連名称 | 10.1371/journal.pone.0278951 | |||||
権利 | ||||||
権利情報 | © 2022 Ichiyama et al. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |