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Therapeutic Potential of Valproic Acid for Postviral Olfactory Dysfunction: A Single-Arm Pilot Study.
http://hdl.handle.net/10422/00013381
http://hdl.handle.net/10422/000133815414ccd5-9b02-4933-aebe-9ed3a758b78f
名前 / ファイル | ライセンス | アクション |
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00034894221111245 (331.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-02 | |||||
タイトル | ||||||
タイトル | Therapeutic Potential of Valproic Acid for Postviral Olfactory Dysfunction: A Single-Arm Pilot Study. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | postviral | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | olfactory dysfunction | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | valproic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | treatment | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | recovery | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | post-infectious | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | prognostic factor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Toki-shakuyaku-san | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | zinc | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
OGAWA, Takao
× OGAWA, Takao× MATSUMOTO, Koji× TOJIMA, Ichiro× KIKUOKA, Hirotaka× HIRA, Daiki× SHIMIZU, Takeshi |
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著者別名 |
小河, 孝夫
× 小河, 孝夫× 松本, 晃治× 戸嶋, 一郎× 菊岡, 弘高× 平, 大樹× 清水, 猛史 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: Although some patients with postviral olfactory dysfunction (PVOD) recover spontaneously, many others are left with the degree of smell loss and there are no established drugs for the treatment of patients with PVOD. Valproic acid (VPA) has been widely used for the treatment of epilepsy. Its potential neuroregenerative effects have been shown via animal studies. This is the first study to treat PVOD patients with VPA. This open-label, single-arm, phase II study was conducted to investigate the effects of VPA in patients with PVOD. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: The patients received oral tablets of VPA 200 mg twice a day for 24 weeks. In total, 11 patients with PVOD were recruited. Oder scores of recognition and detection threshold (measured with a T&T olfactometer), and visual analog scale were examined during the treatment. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: All odor scores significantly improved over time. Although the mean duration of olfactory dysfunction in this study was 11.5 months, both odor recognition threshold and odor detection threshold scores significantly improved 4 weeks after treatment initiation compared to the pre-treatment threshold scores. The olfactory recovery rates in patients treated with VPA were clearly better than those we previously reported in PVOD patients who received Toki-shakuyaku-san, the traditional treatment in Japan. The olfactory recovery rates of patients with PVOD at 12 weeks and 24 weeks of VPA treatment were both 77.8%, and the olfactory cure rates at 12 weeks and 24 weeks of VPA treatment were 33.3% and 44.4%, respectively. No serious adverse events were observed. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusions: VPA seems to be a safe treatment option in patients with PVOD. The effects of VPA treatment for PVOD patients should be studied with a controlled study design in the future. |
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書誌情報 |
en : The Annals of otology, rhinology, and laryngology p. 34894221111245, 発行日 2022-07-13 |
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出版者 | ||||||
出版者 | SAGE Publications Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1943-572X | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35833237 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1177/00034894221111245 | |||||
関連名称 | 10.1177/00034894221111245 | |||||
権利 | ||||||
権利情報 | © 2022, © SAGE Publications | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |