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A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial
http://hdl.handle.net/10422/00013300
http://hdl.handle.net/10422/00013300488d1c36-733a-4011-8efb-0eb917ed6824
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-05-24 | |||||
タイトル | ||||||
タイトル | A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HLH-2004 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hemophagocytic lymphohistiocytosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Epstein–Barr virus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | EBV–HLH | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Complications | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
ONO, Rintaro
× ONO, Rintaro× SAKAMOTO, Kenichi× DOI, Takehiko× YANAGISAWA, Ryu× TAMURA, Akihiro× HASHIMOTO, Hiroya× KANEGANE, Hirokazu× ISHII, Eiichi× NAKAZAWA, Yozo× SHIODA, Yoko |
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著者別名 |
坂本, 謙一
× 坂本, 謙一 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although clinical trials have reported an improvement in the prognosis of hemophagocytic lymphohistiocytosis (HLH), current treatment outcomes are unsatisfactory, especially in severe cases. Most clinical trial patients with severe disease discontinue participation due to complications associated with HLH or treatment-related toxicity. A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial was conducted to review the detailed course of these cases to optimize HLH treatment and supportive care. Findings in these patients were compared with those of 45 patients who completed the protocol treatment. The 3 year overall survival rate of patients who completed treatment was 86.7%, versus 50.7% for those who did not complete treatment. Incidence of serious adverse events, such as infections, coagulopathy, and posterior reversible encephalopathy syndrome, during the initial 8 weeks of treatment was much higher in patients who did not complete treatment than in patients who completed treatment. To improve overall outcomes of patients with HLH, it is important to not only optimize HLH-directed therapy but also provide appropriate supportive care. | |||||
書誌情報 |
en : International Journal of Hematology 発行日 2022-05-06 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0925-5710 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 35524025 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s12185-022-03357-1 | |||||
関連名称 | 10.1007/s12185-022-03357-1 | |||||
権利 | ||||||
権利情報 | © 2022. Japanese Society of Hematology. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |