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Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
http://hdl.handle.net/10422/00013079
http://hdl.handle.net/10422/00013079191b5830-7632-4be7-965f-0935388b001a
名前 / ファイル | ライセンス | アクション |
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srep06309 (255.3 kB)
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This work is licensed under a Creative Commons Attribution-
NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2021-09-22 | |||||||||||
タイトル | ||||||||||||
タイトル | Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder. | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Circadian rhythms and sleep | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | Genetic association study | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
HIDA, Akiko
× HIDA, Akiko× KITAMURA, Shingo× KATAYOSE, Yasuko× KATO, Mie× ONO, Hiroko× 角谷, 寛
WEKO
6474
× UCHIYAMA, Makoto× EBISAWA, Takashi× INOUE, Yuichi× KAMEI, Yuichi× OKAWA, Masako× TAKAHASHI, Kiyohisa× MISHIMA, Kazuo |
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著者別名 |
角谷, 寛
× 角谷, 寛
WEKO
6474
× 大川, 匡子 |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes. | |||||||||||
書誌情報 |
en : Scientific Reports 巻 4, 発行日 2014-09-09 |
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出版者 | ||||||||||||
出版者 | Springer Nature | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 2045-2322 | |||||||||||
PMID | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 25201053 | |||||||||||
PMCID | ||||||||||||
識別子タイプ | URI | |||||||||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4158573/ | |||||||||||
関連名称 | PMC4158573 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.1038/srep06309 | |||||||||||
関連名称 | 10.1038/srep06309 | |||||||||||
権利 | ||||||||||||
権利情報 | © 2014, The Author(s) | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | ||||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
資源タイプ | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | Journal Article |