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Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome.
http://hdl.handle.net/10422/00012919
http://hdl.handle.net/10422/000129195ae40997-d126-40b7-b8b0-712c1944bd8f
名前 / ファイル | ライセンス | アクション |
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s41375-021-01157-w (1.8 MB)
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© The Author(s), under exclusive licence to Springer Nature Limited 2021
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-01 | |||||
タイトル | ||||||
タイトル | Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chemotherapy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Risk factors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TAGA, Takashi
× TAGA, Takashi× TANAKA, Shiro× HASEGAWA, Daisuke× TERUI, Kiminori× TOKI, Tsutomu× IWAMOTO, Shotaro× HIRAMATSU, Hidefumi× MIYAMURA, Takako× HASHII, Yoshiko× MORITAKE, Hiroshi× NAKAYAMA, Hideki× TAKAHASHI, Hiroyuki× SHIMADA, Akira× TAKI, Tomohiko× ITO, Etsuro× HAMA, Asahito× ITO, Masafumi× KOH, Katsuyoshi× HASEGAWA, Daiichiro× SAITO, Akiko M.× ADACHI, Souichi× TOMIZAWA, Daisuke |
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著者別名 |
多賀, 崇
× 多賀, 崇 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Myeloid leukemia of Down syndrome (ML-DS) is associated with good response to chemotherapy, resulting in favorable outcomes. However, no universal prognostic factors have been identified to date. To clarify a subgroup with high risk of relapse, the role of minimal residual disease (MRD) was explored in the AML-D11 trial by the Japanese Pediatric Leukemia/Lymphoma Study Group. MRD was prospectively evaluated at after induction therapy and at the end of all chemotherapy, using flow cytometry (FCM-MRD) and GATA1-targeted deep sequencing (GATA1-MRD). A total of 78 patients were eligible and 76 patients were stratified to the standard risk (SR) group by morphology. In SR patients, FCM-MRD and GATA1-MRD after induction were positive in 5/65 and 7/59 patients, respectively. Three-year event-free survival (EFS) and overall survival (OS) rates were 93.3% and 95.0% in the FCM-MRD-negative population, and 60.0% and 80.0% in the positive population. Three-year EFS and OS rates were both 96.2% in the GATA1-MRD-negative population, and 57.1% and 71.4% in the positive population. Adjusted hazard ratios for associations of FCM-MRD or GATA1-MRD with EFS were 10.98 (p = 0.01) and 27.68 (p < 0.01), respectively. Detection of MRD by either FCM or GATA1 after initial induction therapy represents a significant prognostic factor for predicting ML-DS relapse. | |||||
書誌情報 |
en : Leukemia 巻 35, 号 9, p. 2508-2516, 発行日 2021-02-15 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 33589754 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41375-021-01157-w | |||||
関連名称 | 10.1038/s41375-021-01157-w | |||||
権利 | ||||||
権利情報 | © The Author(s), under exclusive licence to Springer Nature Limited 2021 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10422/00013077 | |||||
関連名称 | Correction to |