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Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils.
http://hdl.handle.net/10422/00012911
http://hdl.handle.net/10422/000129116a75a1f1-813e-47d2-b270-de433a4f91a0
名前 / ファイル | ライセンス | アクション |
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j.biomaterials.2021.120686 (4.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-16 | |||||
タイトル | ||||||
タイトル | Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Alzheimer's disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Curcumin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Keto–enol tautomerism | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oligomer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | β-amyloid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
YANAGISAWA, Daijiro
× YANAGISAWA, Daijiro× KATO, Tomoko× TAGUCHI, Hiroyasu× SHIRAI, Nobuaki× HIRAO, Koichi× SOGABE, Takayuki× TOMIYAMA, Takami× GAMO, Keizo× HIRAHARA, Yukie× KITADA, Masaaki× TOOYAMA, Ikuo |
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著者別名 |
柳沢, 大治郎
× 柳沢, 大治郎× 加藤, 智子× 田口, 弘康× 遠山, 育夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The accumulation of β-amyloid (Aβ) aggregates in the brain occurs early in the progression of Alzheimer's disease (AD), and non-fibrillar soluble Aβ oligomers are particularly neurotoxic. During binding to Aβ fibrils, curcumin, which can exist in an equilibrium state between its keto and enol tautomers, exists predominantly in the enol form, and binding activity of the keto form to Aβ fibrils is much weaker. Here we described the strong binding activity the keto form of curcumin derivative Shiga-Y51 shows for Aβ oligomers and its scant affinity for Aβ fibrils. Furthermore, with imaging mass spectrometry we revealed the blood-brain barrier permeability of Shiga-Y51 and its accumulation in the cerebral cortex and the hippocampus, where Aβ oligomers were mainly localized, in a mouse model of AD. The keto form of curcumin derivatives like Shiga-Y51 could be promising seed compounds to develop imaging probes and therapeutic agents targeting Aβ oligomers in the brain. | |||||
書誌情報 |
en : Biomaterials 巻 270, p. 120686, 発行日 2021-01-23 |
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出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1878-5905 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 33540171 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.biomaterials.2021.120686 | |||||
関連名称 | 10.1016/j.biomaterials.2021.120686 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |