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The mean aqueous VEGF level was significantly higher in eyes with recurrence after loading treatment than in eyes without recurrence (107.6 vs. 83.8 pg/mL, respectively; P = 0.04) and significantly higher in eyes with recurrence within 3 months after loading treatment than in other eyes (114.9 vs. 86.7 pg/mL, respectively; P \u003c 0.01). ", "subitem_description_type": "Abstract"}, {"subitem_description": "Conclusion:\nPretreatment aqueous VEGF level was significantly correlated with the likelihood of recurrence in neovascular age-related macular degeneration. The measurement of pretreatment aqueous VEGF level may be useful to determine the best treatment options for patients with neovascular age-related macular degeneration. 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THE CORRELATION BETWEEN AQUEOUS VASCULAR ENDOTHELIAL GROWTH FACTOR LEVEL AND CLINICAL ACTIVITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.
http://hdl.handle.net/10422/00012891
http://hdl.handle.net/10422/00012891f4b771d4-1720-45e6-a6c0-dd017fe26067
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-19 | |||||
タイトル | ||||||
タイトル | THE CORRELATION BETWEEN AQUEOUS VASCULAR ENDOTHELIAL GROWTH FACTOR LEVEL AND CLINICAL ACTIVITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | age-related macular degeneration | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | vascular endothelial growth factor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aqueous humor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | clinical activity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
ICHIYAMA, Yusuke
× ICHIYAMA, Yusuke× SAWADA, Tomoko× SAWADA, Osamu× ITO, Yuka× KAKINOKI, Masashi× OBATA, Shumpei× SAISHIN, Yoshitsugu× OHJI, Masahito |
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著者別名 |
一山, 悠介
× 一山, 悠介× 澤田, 智子× 澤田, 修× 伊藤, 友香× 柿木, 雅志× 小幡, 峻平× 西信, 良嗣× 大路, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: The aim of the current study was to investigate the correlation between the pretreatment aqueous level of vascular endothelial growth factor (VEGF) and clinical activity in neovascular age-related macular degeneration. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: Patients with neovascular age-related macular degeneration treated by intravitreal ranibizumab injections and followed for 12 months were included in the current study. The treatment regimen consisted of three consecutive monthly intravitreal ranibizumab injections (loading treatment) followed by a pro re nata (PRN) treatment regimen. The aqueous VEGF levels were measured by enzyme-linked immunosorbent assay using aqueous humor samples obtained just before the first intravitreal ranibizumab injections. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Sixty-four eyes of 64 patients were included in the current study. The mean number of intravitreal ranibizumab injections during 12 months was 4.6 ± 1.4, and 17 eyes had no recurrence after loading treatment. The mean aqueous VEGF level was significantly higher in eyes with recurrence after loading treatment than in eyes without recurrence (107.6 vs. 83.8 pg/mL, respectively; P = 0.04) and significantly higher in eyes with recurrence within 3 months after loading treatment than in other eyes (114.9 vs. 86.7 pg/mL, respectively; P < 0.01). |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: Pretreatment aqueous VEGF level was significantly correlated with the likelihood of recurrence in neovascular age-related macular degeneration. The measurement of pretreatment aqueous VEGF level may be useful to determine the best treatment options for patients with neovascular age-related macular degeneration. |
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書誌情報 |
en : Retina (Philadelphia, Pa.) 巻 41, 号 1, p. 111-117, 発行日 2021-01-01 |
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出版者 | ||||||
出版者 | Lippincott Williams & Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1539-2864 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32134804 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1097/iae.0000000000002790 | |||||
関連名称 | 10.1097/IAE.0000000000002790 | |||||
権利 | ||||||
権利情報 | Copyright © by Ophthalmic Communications Society, Inc. Unauthorized reproduction of this article is prohibited. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |