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Citrullinated fibrinogen is a target of auto-antibodies in interstitial lung disease in mice with collagen-induced arthritis.
http://hdl.handle.net/10422/00012771
http://hdl.handle.net/10422/00012771e9fdeb5c-14b2-4b10-a076-67df5643e490
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-08-12 | |||||
タイトル | ||||||
タイトル | Citrullinated fibrinogen is a target of auto-antibodies in interstitial lung disease in mice with collagen-induced arthritis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | citrullination | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | inflammation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | macrophages | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | rheumatoid arthritis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | usual interstitial pneumonia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
SATO, Tomomi
× SATO, Tomomi× SATOOKA, Hiroki× ICHIOKA, Satoko× MARUO, Yoshihiro× HIRATA, Takako |
|||||
著者別名 |
佐藤, 知実
× 佐藤, 知実× 里岡, 大樹× 一岡, 聡子× 丸尾, 良浩× 平田, 多佳子 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interstitial lung disease (ILD) is a very common and lethal complication of rheumatoid arthritis (RA), yet its pathogenesis is not well understood, in part due to the lack of adequate animal models. Although collagen-induced arthritis (CIA) is the most widely used animal model for RA, the lung involvement occurring in this model has scarcely been studied. To evaluate the suitability of CIA as a model for RA-associated ILD (RA-ILD), we immunized DBA/1 mice with bovine type II collagen and characterized lung disease in this model. Histologic analyses revealed patchy interstitial infiltration of inflammatory cells in the peripheral regions of the lung, notably in the subpleural region, in mice with CIA. This pattern resembled usual interstitial pneumonia in humans, which is the most prevalent pattern in RA-ILD. Among infiltrates in the lung, CD11bhi macrophages of the M2 phenotype were most prominently increased. IgG and C3 were deposited in the subpleural region where inflammatory cells infiltrated. The sera from CIA mice contained auto-antibodies against citrullinated proteins, which are specific and predictive markers for RA. Protein citrullination was enhanced in the lung of CIA mice compared with naive mice, and citrullinated fibrinogen was primarily targeted by these auto-antibodies. The elevation of auto-antibodies against citrullinated proteins and their deposition in the lung with patchy subpleural preponderance suggest that CIA can serve as a model to study the pathogenesis of RA-ILD. | |||||
書誌情報 |
en : International immunology 巻 32, 号 8, p. 533-545, 発行日 2020-07-28 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1460-2377 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32239143 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/intimm/dxaa021 | |||||
関連名称 | 10.1093/intimm/dxaa021 | |||||
権利 | ||||||
権利情報 | © The Japanese Society for Immunology. 2020. All rights reserved. | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |