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Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.
http://hdl.handle.net/10422/00012723
http://hdl.handle.net/10422/000127239951e7cf-554d-4d4f-a03e-2472840e0ae3
名前 / ファイル | ライセンス | アクション |
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s41598-020-65488-x (2.5 MB)
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-19 | |||||
タイトル | ||||||
タイトル | Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SATOOKA, Hiroki
× SATOOKA, Hiroki× ISHIGAKI, Hirohito× TODO, Kagefumi× TERADA, Koji× AGATA, Yasutoshi× ITOH, Yasushi× OGASAWARA, Kazumasa× HIRATA, Takako |
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著者別名 |
里岡, 大樹
× 里岡, 大樹× 石垣, 宏仁× 藤堂, 景史× 寺田, 晃士× 縣, 保年× 伊藤, 靖× 小笠原, 一誠× 平田, 多佳子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Immunotherapy has emerged as a promising and effective treatment for cancer, yet the clinical benefit is still variable, in part due to insufficient accumulation of immune effector cells in the tumour microenvironment. Better understanding of tumour-infiltrating lymphocytes (TILs) from nonhuman primate tumours could provide insights into improving effector cell accumulation in tumour tissues during immunotherapy. Here, we characterize TILs in a cynomolgus macaque tumour model in which the tumours were infiltrated with CD4+ and CD8+ T cells and were eventually rejected. The majority of CD4+ and CD8+ TILs exhibited a CD45RA-CCR7- effector memory phenotype, but unlike circulating T cells, they expressed CD69, a marker for tissue-resident memory T (TRM) cells. CD69-expressing CD8+ TILs expressed high levels of the cytotoxic molecule granzyme B and the co-inhibitory receptor PD-1. Consistent with the TRM cell phenotype, CD8+ TILs minimally expressed CX3CR1 but expressed CXCR3 at higher levels than circulating CD8+ T cells. Meanwhile, CXCL9, CXCL10 and CXCL11, chemokine ligands for CXCR3, were expressed at high levels in the tumours, thus attracting CXCR3+CD8+ T cells. These results indicate that tumour-transplanted macaques can be a useful preclinical model for studying and optimizing T cell accumulation in tumours for the development of new immunotherapies. | |||||
書誌情報 |
en : Scientific Reports 巻 10, 号 1, p. 8414, 発行日 2020-05-21 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 32439888 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7242367/ | |||||
関連名称 | PMC7242367 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41598-020-65488-x | |||||
関連名称 | 10.1038/s41598-020-65488-x | |||||
権利 | ||||||
権利情報 | © The Author(s) 2020 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |