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Expressions of ezrin, ERK, STAT3, and AKT in tongue cancer and association with tumor characteristics and patient survival.
http://hdl.handle.net/10422/00012712
http://hdl.handle.net/10422/000127124621fea7-5a38-4105-b0f5-cfb81f735abb
名前 / ファイル | ライセンス | アクション |
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cre2.293 (1.6 MB)
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© 2020 The Authors.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expressions of ezrin, ERK, STAT3, and AKT in tongue cancer and association with tumor characteristics and patient survival. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | AKT | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ERK | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | the 5-year survival rate | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tongue squamous cell carcinoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
NOI, Masaharu
× NOI, Masaharu× MUKAISHO, Ken-ichi× MURAKAMI, Shoko× KOSHINUMA, Shinya× MACHIDA, Yoshisato× YAMORI, Masashi× NAKAYAMA, Takahisa× OGAWA, Takao× NAKATA, Yusuke× SHIMIZU, Takeshi× YAMAMOTO, Gaku× SUGIHARA, Hiroyuki |
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著者別名 |
野井, 将大
× 野井, 将大× 向所, 賢一× 村上, 翔子× 越沼, 伸也× 町田, 好聡× 家森, 正志× 仲山, 貴永× 小河, 孝夫× 中多, 祐介× 清水, 猛史× 山本, 学× 杉原, 洋行 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ezrin, ERK, STAT3, and AKT are proteins that are overexpressed in various types of cancer, although their expressions in tongue cancer has received less focus. This study aimed to address associations between the expression levels of these proteins and with characteristics of the tumor and patient survival. We performed immunohistochemical staining of ezrin, ERK, STAT3, and AKT in tumors from patients with tongue carcinoma in situ (CIS, n = 17) and tongue squamous cell carcinoma (SCC, n = 46). Statistical differences between the SCC versus the CIS cohorts were estimated by calculations of bivariate odds ratios of low versus high expression of the proteins. Fisher's exact tests were used to appraise interassociations between the proteins, as well as expression levels versus patient and tumor characteristics. Survival based on Kaplan-Meier statistics in combination log-rank tests were used to address potential effects of the patient and tumor characteristics versus 5-year survival rate. The relative high: low expression of all four proteins in the two cohorts differed, and particularly ERK was markedly overexpressed in the SCC versus the CIS cohort (odds ratio = 45.3, p < .01). The relative high: low expression each protein versus patient and tumor characteristics; showed associations between AKT expression and T stage (p = .002) plus node metastases (p = .12), and between ERK expression and drinking (p = .01) and smoking history (p = .01). There was no significant difference observed between ERK and the three other molecules, nor any significant difference between the degree of expression of each protein and the 5-year disease-specific survival rate. Ezrin, ERK, STAT3, and AKT appear to be involved in the progress from carcinoma in situ in the tongue into squamous cell carcinoma. ERK in particular is overexpressed, suggesting that ERK may be a novel therapeutic target for preventing tongue cancer. | |||||
言語 | en | |||||
書誌情報 |
en : Clinical and experimental dental research 巻 6, 号 4, p. 420-427, 発行日 2020-04-13 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Wiley | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2057-4347 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32281236 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1002/cre2.293 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2020 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |