WEKO3
アイテム
{"_buckets": {"deposit": "d1c8924b-e14d-4d87-b1bb-3111298dc81d"}, "_deposit": {"created_by": 11, "id": "2815", "owners": [11], "pid": {"revision_id": 0, "type": "depid", "value": "2815"}, "status": "published"}, "_oai": {"id": "oai:shiga-med.repo.nii.ac.jp:00002815", "sets": ["37"]}, "author_link": [], "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-09-23", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageStart": "e75910", "bibliographicVolumeNumber": "8", "bibliographic_titles": [{"bibliographic_title": "PLoS one", "bibliographic_titleLang": "en"}]}]}, "item_6_date_granted_70": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2014-03-10"}]}, "item_6_degree_grantor_68": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "滋賀医科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "14202", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_67": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Pandemic (H1N1) 2009 influenza virus spread throughout the world since most people did not have immunity against the virus. In the post pandemic phase when many humans might possess immunity against the pandemic virus, one of the concerns is infection in immunocompromised people. Therefore, we used an immunosuppressed macaque model to examine pathogenicity of the pandemic (H1N1) 2009 virus under an immunocompromised condition. The virus in nasal samples of immunosuppressed macaques infected with the pandemic (H1N1) 2009 virus was detected longer after infection than was the virus in nasal samples of immunocompetent macaques. As expected, not only virus amounts but also virus propagation sites in the immunosuppressed macaques were larger than those in lungs of the immunocompetent macaques when they were infected with the pandemic virus. Immunosuppressed macaques possessed low levels of immune cells producing cytokines and chemokines, but levels of inflammatory cytokines/chemokine interleukin (IL)-6, IL-18, and monocyte chemotactic protein (MCP)-1 in lungs of the immunosuppressed macaques were higher than those in lungs of the immunocompetent macaques, though the differences were not statistically significant. Therefore, under an immunosuppressive condition, the pandemic influenza (H1N1) 2009 virus might cause more severe morbidity with high cytokine/chemokine production by the host innate immune system than that seen in macaques under the immunocompetent condition. ", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_42": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "Thesis or Dissertation", "subitem_description_type": "Other"}]}, "item_6_description_69": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "平成25年度", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_71": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第707号"}]}, "item_6_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "PLoS one", "subitem_publisher_language": "en"}]}, "item_6_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "24086663", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1371/journal.pone.0075910"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1371/journal.pone.0075910", "subitem_relation_type_select": "DOI"}}]}, "item_6_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1932-6203", "subitem_source_identifier_type": "PISSN"}]}, "item_6_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "PHAM, Van Lo", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "journal.pone.0075910.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "journal.pone.0075910.pdf", "objectType": "fulltext", "url": "https://shiga-med.repo.nii.ac.jp/record/2815/files/journal.pone.0075910.pdf"}, "version_id": "2736ee5a-5293-4cb0-b591-8a8f7abba7d4"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques.", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "11", "path": ["37"], "permalink_uri": "http://hdl.handle.net/10422/7356", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-09-22"}, "publish_date": "2014-09-22", "publish_status": "0", "recid": "2815", "relation": {}, "relation_version_is_last": true, "title": ["Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques."], "weko_shared_id": -1}
Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques.
http://hdl.handle.net/10422/7356
http://hdl.handle.net/10422/73561f21be4f-4740-47db-9f35-21341a8e42d0
名前 / ファイル | ライセンス | アクション |
---|---|---|
journal.pone.0075910.pdf (2.3 MB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
---|---|---|---|---|---|---|---|---|
公開日 | 2014-09-22 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques. | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
PHAM, Van Lo
× PHAM, Van Lo
|
|||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Pandemic (H1N1) 2009 influenza virus spread throughout the world since most people did not have immunity against the virus. In the post pandemic phase when many humans might possess immunity against the pandemic virus, one of the concerns is infection in immunocompromised people. Therefore, we used an immunosuppressed macaque model to examine pathogenicity of the pandemic (H1N1) 2009 virus under an immunocompromised condition. The virus in nasal samples of immunosuppressed macaques infected with the pandemic (H1N1) 2009 virus was detected longer after infection than was the virus in nasal samples of immunocompetent macaques. As expected, not only virus amounts but also virus propagation sites in the immunosuppressed macaques were larger than those in lungs of the immunocompetent macaques when they were infected with the pandemic virus. Immunosuppressed macaques possessed low levels of immune cells producing cytokines and chemokines, but levels of inflammatory cytokines/chemokine interleukin (IL)-6, IL-18, and monocyte chemotactic protein (MCP)-1 in lungs of the immunosuppressed macaques were higher than those in lungs of the immunocompetent macaques, though the differences were not statistically significant. Therefore, under an immunosuppressive condition, the pandemic influenza (H1N1) 2009 virus might cause more severe morbidity with high cytokine/chemokine production by the host innate immune system than that seen in macaques under the immunocompetent condition. | |||||||
言語 | en | |||||||
学位名 | ||||||||
言語 | ja | |||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 14202 | |||||||
言語 | ja | |||||||
学位授与機関名 | 滋賀医科大学 | |||||||
学位授与年度 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 平成25年度 | |||||||
言語 | ja | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2014-03-10 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第707号 | |||||||
書誌情報 |
en : PLoS one 巻 8, 号 9, p. e75910, 発行日 2013-09-23 |
|||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | PLoS one | |||||||
著者版フラグ | ||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 1932-6203 | |||||||
PMID | ||||||||
識別子タイプ | PMID | |||||||
関連識別子 | 24086663 | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | https://doi.org/10.1371/journal.pone.0075910 | |||||||
関連名称 | 10.1371/journal.pone.0075910 | |||||||
資源タイプ | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Thesis or Dissertation |