WEKO3
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drs癌抑制遺伝子による癌化抑制機構(第8回基礎・臨床融合の学内共同研究発表会)(抄録)
http://hdl.handle.net/10422/2858
http://hdl.handle.net/10422/2858b7a24bdb-1bff-4cde-9d88-c5ce219f6a57
名前 / ファイル | ライセンス | アクション |
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jsums2601pa21.pdf (384.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-04-12 | |||||
タイトル | ||||||
タイトル | drs癌抑制遺伝子による癌化抑制機構(第8回基礎・臨床融合の学内共同研究発表会)(抄録) | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Function of tumor suppressor gene, drs | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | drs ガン ヨクセイ イデンシ ニ ヨル ガンカ ヨクセイ キコウ (ダイ 8カイ キソ リンショウ ユウゴウ ノ ガクナイ キョウドウ ケンキュウ ハッピョウカイ)(ショウロク) | |||||
著者 |
旦部, 幸博
× 旦部, 幸博× 井上, 寛一 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The drs gene was originally isolated as a suppressor of v-src transformation. Expression of drs mRNA ismarkedly downregulated in a variety of human cancer cell lines and tissues. Ectopic expression of the Drs protein inducedapoptosis in human cancer cell lines via the novel pathway initiated from the endoplasmic reticulum (ER), involving thebinding to ASY, apoptosis-inducing proteins localized in ER, and activation of caspase-12, -9, and -3. We generated drsknockout (KO) mice and showed that malignant tumors including lymphomas, lung adenocarcinomas and hepatomas weregenerated in about 30% of drs KO mice. These results indicate that drs contributes to the suppression of malignant tumorformation, and this suppression is closely correlated with drs-mediated apoptosis. We also investigated the physiological rolesof drs gene by using mouse embryonic fibroblast (MEF) cells derived from drs KO mice, and found that drs is associated withRab24, autophagy regulating protein, and regulates autophagy maturation under low serum culture conditions. Furthermore,drs suppresses viral replication via mTOR-dependent pathway. These results suggest that drs is involved in the protectiveresponses of the cells against the carcinogenesis and viral infection. | |||||
書誌情報 |
滋賀医科大学雑誌 巻 26, 号 1, p. a21-a25, 発行日 2013-02-25 |
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出版者 | ||||||
出版者 | 滋賀医科大学雑誌編集委員会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Departmental Bulletin Paper |